Prospective evaluation of three different diagnostic criteria for disseminated intravascular coagulation

Tetsushi Takemitsu, Hideo Wada, Tsuyoshi Hatada, Yukinari Ohmori, Ken Ishikura, Taichi Takeda, Takashi Sugiyama, Norikazu Yamada, Kazuo Maruyama, Naoyuki Katayama, Shuji Isaji, Hideto Shimpo, Masato Kusunoki, Tsutomu Nobori

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69 Citations (Scopus)

Abstract

There are three different diagnostic score systems for disseminated intravascular coagulation (DIC) established by the Japanese Ministry Health and Welfare (JMHW), the International Society on Thrombosis and Haemostasis (ISTH) and the Japanese Association for Acute Medicine (JAAM). The JMHW criteria are still used in Japan. In the present study, all three diagnostic criteria were used to prospectively evaluate 413 patients with different underlying diseases of DIC who were treated at the Mie University Hospital (JMHW, n= 166; ISTH, n=143; JAAM, n=291). The odds ratio (95% confidence interval) for death was 1.88 (1.22-2.90) in JMHW, 2.55 (1.65-3.95) in ISHT and 1.99 (1.19-3.32) in JAAM. The platelet count, prothrombin time, fibrin and fibrinogen degradation products and fibrinogen were significantly important for diagnosis of DIC by all three diagnostic criteria. Haemostatic molecular markers were significantly high in all patients and were useful for the diagnosis of DIC. The JAAM diagnostic criteria displayed a high sensitivity for DIC and the ISTH overt-DIC diagnostic criteria displayed a high specificity for DIC. All three diagnostic criteria for DIC were related to a poor patient outcome.

Original languageEnglish
Pages (from-to)40-44
Number of pages5
JournalThrombosis and Haemostasis
Volume105
Issue number1
DOIs
Publication statusPublished - 2011 Jan

Keywords

  • DIC
  • Haemostatic markers
  • ISTH
  • Japanese Ministry Health and Welfare
  • Mortality
  • Resolution rate

ASJC Scopus subject areas

  • Hematology

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    Takemitsu, T., Wada, H., Hatada, T., Ohmori, Y., Ishikura, K., Takeda, T., Sugiyama, T., Yamada, N., Maruyama, K., Katayama, N., Isaji, S., Shimpo, H., Kusunoki, M., & Nobori, T. (2011). Prospective evaluation of three different diagnostic criteria for disseminated intravascular coagulation. Thrombosis and Haemostasis, 105(1), 40-44. https://doi.org/10.1160/TH10-05-0293