TY - JOUR
T1 - Prospective evaluation of hemostatic abnormalities in overt DIC due to various underlying diseases
AU - Kawasugi, Kazuo
AU - Wada, Hideo
AU - Hatada, Tsuyoshi
AU - Okamoto, Kohji
AU - Uchiyama, Toshimasa
AU - Kushimoto, Shigeki
AU - Seki, Yoshinobu
AU - Okamura, Takashi
AU - Nobori, Tsutomu
N1 - Funding Information:
This prospective study was carried out across nine institutes, comprised of the Department of Molecular and Laboratory Medicine and Emergency Medicine of Mie University School of Medicine, the First Department of Surgery of the University of Occupational and Environmental Health School of Medicine, the Department of Internal Medicine of Takasaki National Hospital, Takasaki, the Department of Internal Medicine of Teikyo University School of Medicine, the Department of Emergency Medicine and Intensive Care of the Graduate School of Medicine, Nagoya University, the Department of Anesthesiology and Critical Care Medicine of Hokkaido University Graduate School of Medicine, the Department of Emergency and Critical Care Medicine of Nippon Medical School, the Department of Internal Medicine of Shibata Hospital-Niigata Prefectural Hospital, the Research Division of Cell and Molecular Medicine of the Center for Molecular Medicine, and the Jichi Medical University School of Medicine. This work was supported in part by a Grant-in-Aid from the Ministry of Health, Labour and Welfare of Japan for Blood Coagulation Abnormalities and from the Ministry of Education, Culture, Sports, Science and Technology of Japan.
PY - 2011/8
Y1 - 2011/8
N2 - Patients with suspected disseminated intravascular coagulation (DIC) were prospectively evaluated for various types of underlying diseases, and the usefulness of hemostatic markers were examined for each patient with DIC due to various underlying diseases. The main underlying disease of DIC was infectious diseases, hematologic malignancies, and solid tumors, and a high resolution rate from DIC was observed in obstetric diseases and hematologic malignancies. The diagnosis of DIC was related to a poor outcome in trauma/burn victims and those with infectious disease. In the main underlying disease, it is suggested that DIC would be excluded in patients with hematologic malignancies or solid tumors with a platelet count of more than 100,000/μl and in the patients with an FDP of less than 10 μg/ml, and fibrinogen of less than 100 mg/dl, suggesting the presence of DIC. The prothrombin time was a sensitive marker, but fibrinogen levels were not sensitive for DIC due to infectious diseases. The plasmin plasmin inhibitor complex in hematologic malignancy, and soluble fibrin monomer complex, antithrombin and thrombomodulin in patients with infectious disease, were sensitive markers for the diagnosis of DIC. Although hemostatic markers were useful for the diagnosis of DIC, the usefulness varied depending on the different underlying diseases.
AB - Patients with suspected disseminated intravascular coagulation (DIC) were prospectively evaluated for various types of underlying diseases, and the usefulness of hemostatic markers were examined for each patient with DIC due to various underlying diseases. The main underlying disease of DIC was infectious diseases, hematologic malignancies, and solid tumors, and a high resolution rate from DIC was observed in obstetric diseases and hematologic malignancies. The diagnosis of DIC was related to a poor outcome in trauma/burn victims and those with infectious disease. In the main underlying disease, it is suggested that DIC would be excluded in patients with hematologic malignancies or solid tumors with a platelet count of more than 100,000/μl and in the patients with an FDP of less than 10 μg/ml, and fibrinogen of less than 100 mg/dl, suggesting the presence of DIC. The prothrombin time was a sensitive marker, but fibrinogen levels were not sensitive for DIC due to infectious diseases. The plasmin plasmin inhibitor complex in hematologic malignancy, and soluble fibrin monomer complex, antithrombin and thrombomodulin in patients with infectious disease, were sensitive markers for the diagnosis of DIC. Although hemostatic markers were useful for the diagnosis of DIC, the usefulness varied depending on the different underlying diseases.
KW - DIC
KW - Global coagulation test
KW - Hemostatic molecular marker
KW - Mortality
KW - Underlying disease
UR - http://www.scopus.com/inward/record.url?scp=79960408858&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79960408858&partnerID=8YFLogxK
U2 - 10.1016/j.thromres.2011.02.015
DO - 10.1016/j.thromres.2011.02.015
M3 - Article
C2 - 21429565
AN - SCOPUS:79960408858
VL - 128
SP - 186
EP - 190
JO - Thrombosis Research
JF - Thrombosis Research
SN - 0049-3848
IS - 2
ER -