Prospective evaluation of hemostatic abnormalities in overt DIC due to various underlying diseases

Kazuo Kawasugi, Hideo Wada, Tsuyoshi Hatada, Kohji Okamoto, Toshimasa Uchiyama, Shigeki Kushimoto, Yoshinobu Seki, Takashi Okamura, Tsutomu Nobori

Research output: Contribution to journalArticlepeer-review

33 Citations (Scopus)


Patients with suspected disseminated intravascular coagulation (DIC) were prospectively evaluated for various types of underlying diseases, and the usefulness of hemostatic markers were examined for each patient with DIC due to various underlying diseases. The main underlying disease of DIC was infectious diseases, hematologic malignancies, and solid tumors, and a high resolution rate from DIC was observed in obstetric diseases and hematologic malignancies. The diagnosis of DIC was related to a poor outcome in trauma/burn victims and those with infectious disease. In the main underlying disease, it is suggested that DIC would be excluded in patients with hematologic malignancies or solid tumors with a platelet count of more than 100,000/μl and in the patients with an FDP of less than 10 μg/ml, and fibrinogen of less than 100 mg/dl, suggesting the presence of DIC. The prothrombin time was a sensitive marker, but fibrinogen levels were not sensitive for DIC due to infectious diseases. The plasmin plasmin inhibitor complex in hematologic malignancy, and soluble fibrin monomer complex, antithrombin and thrombomodulin in patients with infectious disease, were sensitive markers for the diagnosis of DIC. Although hemostatic markers were useful for the diagnosis of DIC, the usefulness varied depending on the different underlying diseases.

Original languageEnglish
Pages (from-to)186-190
Number of pages5
JournalThrombosis Research
Issue number2
Publication statusPublished - 2011 Aug
Externally publishedYes


  • DIC
  • Global coagulation test
  • Hemostatic molecular marker
  • Mortality
  • Underlying disease

ASJC Scopus subject areas

  • Hematology


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