Pros-Eight™ Transurethral Radiofrequency Thermotherapy for Benign Prostatic Hyperplasia: Preliminary Clinical Results

Osamu Yoshida, Akito Terai, Yasumasa Shichiri, Yusaku Okada, Satoshi Ishitoya, Kazutoshi Okubo, Yuji Suzuki, Yoichi Arai

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Background: We have developed a new transurethral thermotherapy device using 8MHz radiofrequency (RF) for the treatment of patients with symptomatic benign prostatic hyperplasia (BPH). We report the safety and effectiveness of the initial clinical experience with this device. Methods: Sixty patients with symptomatic BPH were subjected to a single 1-hour treatment under local anesthesia. The treatment device uses extracorporeal RF capacitive heating in combination with radiative heating and conductive cooling of the urethra. Results: In the 49 patients evaluable at 3 months, the mean International Prostate Symptom Score decreased from 17.8 to 1.3.1 (P < 0.0001) and the Quality of Life score decreased from 4.4 to 3.4 (P < 0.0005). Maximum flow rate increased from 8.1 to 9.7 mL/s (P < 0.05) at 3 months. Overall effectiveness by Homma's response criteria was as follows; excellent 4.1%, good 10.2%, fair 38.8% and poor 46.9%. Side effects were minimal. Gross hematuria was seen in 3 patients and erosion of the external urethral meatus was seen in 2 patients, but none had urinary retention. Conclusions: In this initial clinical trial, transurethral RF thermotherapy was safe and resulted in modest symptomatic improvement. Further investigations for optimizing the treatment protocol seem warranted.

Original languageEnglish
Pages (from-to)454-458
Number of pages5
JournalInternational Journal of Urology
Volume3
Issue number6
DOIs
Publication statusPublished - 1996

Keywords

  • Benign prostatic hyperplasia
  • Capacitive heating
  • Transurethral radiofrequency thermotherapy

ASJC Scopus subject areas

  • Urology

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