Prophylactic effect of dietary seaweed fucoidan against enteral prion infection

Katsumi Doh-Ura, Tomoko Kuge, Miyuki Uomoto, Keiko Nishizawa, Yuri Kawasaki, Masahiko Iha

Research output: Contribution to journalArticlepeer-review

33 Citations (Scopus)

Abstract

Dietary seaweed fucoidan delays the onset of disease of enterally infected mice with scrapie when given orally for 6 days after infection, but not when given before the infection. This effect was not modified at a tested fucoidan dose range and appeared to reach the maximum level at a concentration of 2.5% or less in feed. Daily uptake of fucoidan might be prophylactic against prion diseases caused by ingestion of prion-contaminated materials, although further evaluation of its pharmacology remains to be done.

Original languageEnglish
Pages (from-to)2274-2277
Number of pages4
JournalAntimicrobial agents and chemotherapy
Volume51
Issue number6
DOIs
Publication statusPublished - 2007 Jun

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

Fingerprint Dive into the research topics of 'Prophylactic effect of dietary seaweed fucoidan against enteral prion infection'. Together they form a unique fingerprint.

Cite this