Abstract
An anion channel from Drosophila neurosn had the selectivity sequence: NO3-(1.97)>Br-(1.12) ≈ I-(1.03) ≈ Cl-(1)>F-(0.32) ≫ glutamate(< 0.02) as estimated by the permeability ratio based on the reversal potential measurement. 4-Acetoamido-4′-isothiocyanostilbene-2,2′-disulfonic acid applied internally at 10 μM blocked the channel. We suggest that the chloride channel identified here may provide a pathway for Cl- in the resting membrane of Drosophila neurons.
Original language | English |
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Pages (from-to) | 187-190 |
Number of pages | 4 |
Journal | BBA - Biomembranes |
Volume | 986 |
Issue number | 1 |
DOIs | |
Publication status | Published - 1989 Nov 17 |
Keywords
- (Drosophila)
- Channel selectivity
- Chloride channel
- Membrane potential
- SITS
- Single-channel conductance
ASJC Scopus subject areas
- Biophysics
- Biochemistry
- Cell Biology