Properties of single chloride channels in primary neuronal cultures of Drosophila

Daisuke Yamamoto, Noboyuki Suzuki

    Research output: Contribution to journalArticlepeer-review

    5 Citations (Scopus)

    Abstract

    An anion channel from Drosophila neurosn had the selectivity sequence: NO3-(1.97)>Br-(1.12) ≈ I-(1.03) ≈ Cl-(1)>F-(0.32) ≫ glutamate(< 0.02) as estimated by the permeability ratio based on the reversal potential measurement. 4-Acetoamido-4′-isothiocyanostilbene-2,2′-disulfonic acid applied internally at 10 μM blocked the channel. We suggest that the chloride channel identified here may provide a pathway for Cl- in the resting membrane of Drosophila neurons.

    Original languageEnglish
    Pages (from-to)187-190
    Number of pages4
    JournalBBA - Biomembranes
    Volume986
    Issue number1
    DOIs
    Publication statusPublished - 1989 Nov 17

    Keywords

    • (Drosophila)
    • Channel selectivity
    • Chloride channel
    • Membrane potential
    • SITS
    • Single-channel conductance

    ASJC Scopus subject areas

    • Biophysics
    • Biochemistry
    • Cell Biology

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