Pronounced enhancement of ·NO-dependent antimicrobial action by an ·NO- oxidizing agent, imidazolineoxyl N-oxide

K. Yoshida, T. Akaike, T. Doi, K. Sato, S. Ijiri, M. Suga, M. Ando, H. Maeda

Research output: Contribution to journalComment/debatepeer-review

54 Citations (Scopus)

Abstract

The antimicrobial action of ·NO against Cryptococcus neoformans was investigated by using imidazolineoxyl N-oxide, which we recently reported removes ·NO via oxidation (T. Akaike, M. Yoshida, Y. Miyamoto, K. Sato, M. Kohno, K. Sasamoto, K. Miyazaki, S. Ueda, and H. Maeda, Biochemistry 32:827- 832, 1993). No appreciable fungicidal activity was observed in neutral ·NO solutions. Imidazolineoxyl N-oxide induced or enhanced fungicidal action in neutral or acidic ·NO solutions, respectively. Our results provide convincing evidence that ·NO is not a microbicidal molecular species.

Original languageEnglish
Pages (from-to)3552-3555
Number of pages4
JournalInfection and immunity
Volume61
Issue number8
Publication statusPublished - 1993 Jan 1
Externally publishedYes

ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Immunology
  • Infectious Diseases

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