Promotion of early osteoclastogenesis and B lymphopoiesis in the bone marrow of transgenic rats with the env-pX gene of human T-cell lymphotropic virus type I

Hidetoshi Yamazaki, Takahiro Kunisada, Akihiro Ishizu, Hitoshi Ikeda, Ichiro Miyoshi, Tetsuo Sudo, Shin Ichi Hayashi, Takashi Yoshiki

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)

Abstract

Human T-cell lymphotropic virus type T (HTLV-I) is associated with various clinical disorders including adult T cell leukemia, myelopathy, arthropathy. Hypercalcemia resulting from osteoclast activation and a variety of hematopoietic abnormalities have been also observed in HTLV-I infected patients, however, precise mechanism about initial trigger(s) prior to presenting symptoms is still unknown. In this study, to assess effects of HTLV-I on hematopoiesis, we analysed characteristics of early hematopoietic precursors in HTLV-I env-pX transgenic rats. Progenitor cells for osteoclasts were significantly increased even in the marrow of asymptomatic env-pX rats. Progenitors for B cells were also highly enriched, while colony forming cells (CFC) elicited by GM-CSF(CFU-GM) and M-CSF(CFU-M) were comparable to normal littermates. Following arthritis in env-pX transgenic rats, osteoclastogenesis was further augmented and the CFCs were increased. Bone marrow cells carrying adjuvant-induced arthritis retained a constant number of progenitors for osteoclast and B lymphocytes, whereas the number of CFU-GM and CFU-M increased. These results indicate that the env-pX transgene affect early stages of osteoclast and B-cell lineages prior to developing diseases, in contrast, an increase of the CFCs was caused indirectly by arthritis. This study provides a novel standpoint for the mechanisms of pathogenesis by HTLV-I.

Original languageEnglish
Pages (from-to)2955-2960
Number of pages6
JournalOncogene
Volume17
Issue number23
DOIs
Publication statusPublished - 1998 Dec 10

Keywords

  • B lymphopoiesis
  • HTLV-I
  • Hematopoiesis
  • Osteoclastogenesis
  • env-pX transgenic rat

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research

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