Prominent increased calcineurin immunoreactivity in the superior temporal gyrus in schizophrenia: A postmortem study

Akira Wada, Yasuto Kunii, Jyunya Matsumoto, Mizuki Hino, Qiaohui Yang, Shin ichi Niwa, Hirooki Yabe

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

Many neuroimaging studies have demonstrated structural changes in the superior temporal gyrus (STG) in patients with schizophrenia. Several postmortem studies have reported on the pathogenesis of schizophrenia, but few reports have investigated alterations in molecules in the STG. In addition, several studies have suggested that calcineurin (CaN) inadequacy may be a risk factor for schizophrenia, but no reports about CaN expression in the STG in schizophrenia have been published. We compared the density of CaN-immunoreactive (CaN-IR) neurons in the STG from 11 patients with schizophrenia with that of 11 sex- and age-matched controls. We used immunohistochemical analysis with rabbit polyclonal antibodies against human CaN. In the STG, the density of CaN-IR neurons in layers II - VI in the group with schizophrenia was significantly higher than that in the control group. Our results confirmed pathological changes in the STG in patients with schizophrenia, suggesting that alterations in the CaN pathway play a role in the pathogenesis of schizophrenia.

Original languageEnglish
Pages (from-to)79-83
Number of pages5
JournalPsychiatry Research
Volume247
DOIs
Publication statusPublished - 2017 Jan 1
Externally publishedYes

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

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