Proline-mediated enantioselective construction of tetrahydropyrans via a domino aldol/acetalization reaction

Damien Hazelard, Hayato Ishikawa, Daisuke Hashizume, Hiroyuki Koshino, Yujiro Hayashi

Research output: Contribution to journalArticlepeer-review

36 Citations (Scopus)

Abstract

(Chemical Equation Presented) Highly enantioselective synthesis of tetrahydropyrans was accomplished via a domino proline-mediated aldol reaction/intramolecular acetal formation from an aldehyde and inexpensive aqueous tetrahydro-2H-pyran-2,6-diol as a five-carbon unit.

Original languageEnglish
Pages (from-to)1445-1448
Number of pages4
JournalOrganic letters
Volume10
Issue number7
DOIs
Publication statusPublished - 2008 Apr 3

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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