Abstract
Prolinate salt is an efficient catalyst in the Mannich reaction of alkynyl imine and aldehyde, to afford synthetically useful chiral propargyl amine derivatives with excellent syn-selectivity and nearly perfect control of the absolute configuration. The counterion of the prolinate salt does not affect the enantioselectivity. This is a rare example, in which proline alkali metals, alkaline-earth metals, or ammonium salt show higher reactivity and better stereoselectivity than the parent proline.
Original language | English |
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Pages (from-to) | 2391-2394 |
Number of pages | 4 |
Journal | Organic letters |
Volume | 20 |
Issue number | 8 |
DOIs | |
Publication status | Published - 2018 Apr 20 |
ASJC Scopus subject areas
- Biochemistry
- Physical and Theoretical Chemistry
- Organic Chemistry