Proliferative fasciitis of the forearm: Case report with immunohistochemical, ultrastructural and dna ploidy studies and a review of the literature

Hironobu Sasano, Hideo Yamaki, Yusuke Ohashi, Syuichi Ohtsuki, Hiroshi Nagura

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

A case of proliferative fasciitis arising in the left forearm of a 56- year-old man was examined. The lesion was preceded by blunt trauma, measured 1.5 x 1.3 x 1.0 cm, was poorly circumscribed and appeared white to light gray on the cut surface. Light microscopic examinations revealed that spindle cells and giant cells with one or two nuclei and abundant basophilic cytoplasm were arranged without any organized patterns in collagenous stroma. Ultrastructurally, well-developed rough endoplasmic reticulum separated by varying amounts of fine to course fibrillar materials was detected in the giant cells. Only vimentin immunoreactivity was detected in both spindle and giant cells. The Ki-67 labeling index of spindle cells was 35% but that of giant cells was less than 5%, and this reflects the quiescent or slow- growing features of these giant cells in proliferative fasciitis. DNA content of the cells, which was examined by image cytometry, demonstrated diploidy in both spindle (DNA index = 1.01) and giant (DNA index = 1.09) cells.

Original languageEnglish
Pages (from-to)486-490
Number of pages5
JournalPathology international
Volume48
Issue number6
DOIs
Publication statusPublished - 1998

Keywords

  • DNA ploidy
  • Immunohistochemistry
  • Proliferative fasciitis
  • Ultrastructure

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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