Project for applications of phase-contrast X-ray imaging to medicine using an X-ray interferometer

Atsushi Momose, Akio Yoneyama, Tohoru Takeda, Yuji Itai, Jinhong Tu, Keiichi Hirano

Research output: Contribution to journalConference articlepeer-review

2 Citations (Scopus)


We are investigating possible medical applications of phase-contrast X-ray imaging using an X-ray interferometer. This paper introduces the strategy of the research project and the present status. The main subject is to broaden the observation area to enable in vivo observation. For this purpose, large X-ray interferometers were developed, and 2.5 cm × 1.5 cm interference patterns were generated using synchrotron X-rays. An improvement of the spatial resolution is also included in the project, and an X-ray interferometer designed for high-resolution phase-contrast X-ray imaging was fabricated and tested. In parallel with the instrumental developments, various soft tissues are observed by phase-contrast X-ray CT to find correspondence between the generated contrast and our histological knowledge. The observation done so far suggests that cancerous tissues are differentiated from normal tissues and that blood can produce phase contrast. Furthermore, this project includes exploring materials that modulate phase contrast for selective imaging.

Original languageEnglish
Pages (from-to)23-31
Number of pages9
JournalProceedings of SPIE - The International Society for Optical Engineering
Publication statusPublished - 1999 Dec 1
Externally publishedYes
EventProceedings of the 1999 1st SPIE Conference on the Medical Applications of Penetrating Radiation - Denver, CO, USA
Duration: 1999 Jul 221999 Jul 23

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering


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