Progressive Cerebral Ischemia and Intracerebral Hemorrhage after Indirect Revascularization for a Patient with Cerebral Proliferative Angiopathy

Tomomi Kimiwada, Toshiaki Hayashi, Misaki Takahashi, Reizo Shirane, Teiji Tominaga

Research output: Contribution to journalArticle

Abstract

We previously reported a patient with cerebral proliferative angiopathy (CPA) who showed cerebral ischemia in resting and acetazolamide-stressed N-isopropyl-p-[ 123 I] iodoamphetamine single-photon emission computed tomography ( 123 I-IMP-SPECT). At onset, the patient was treated conservatively. However, during the 2 years following initial onset, his hemiparesis and aphasia had gradually aggravated and his IQ scores were markedly decreased. MRI revealed progressive vascular proliferation and brain atrophy. 123 I-IMP-SPECT showed more severely impaired cerebral blood flow (CBF) and cerebrovascular reactivity over the affected hemisphere. We performed an indirect revascularization to augment CBF; however, his neurological deficits were not improved and new arteriovenous shunts via extracranial-intracranial bypass were developed, followed by an asymptomatic small intracerebral hemorrhage. There are no reports on CPA patients who have shown cerebral hemorrhage after indirect revascularization. Treatments for CPA are still challenging and controversial. Cases with severe stenosis of the proximal arteries may benefit from indirect revascularization. But indirect bypass should not be indicated for such patients without main arterial stenosis, even if they have persistent ischemia.

Original languageEnglish
Pages (from-to)853-858
Number of pages6
JournalJournal of Stroke and Cerebrovascular Diseases
Volume28
Issue number4
DOIs
Publication statusPublished - 2019 Apr

Keywords

  • Cerebral proliferative angiopathy
  • indirect revascularization
  • intracerebral hemorrhage
  • progressive cerebral ischemia

ASJC Scopus subject areas

  • Surgery
  • Rehabilitation
  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine

Fingerprint Dive into the research topics of 'Progressive Cerebral Ischemia and Intracerebral Hemorrhage after Indirect Revascularization for a Patient with Cerebral Proliferative Angiopathy'. Together they form a unique fingerprint.

  • Cite this