Progressive adult primary glioblastoma in the medulla oblongata with an unmethylated MGMT promoter and without an IDH mutation

Akifumi Yoshikawa, Mitsutoshi Nakada, Takuya Watanabe, Yutaka Hayashi, Hemragul Sabit, Yukinari Kato, Shioto Suzuki, Akishi Ooi, Hiroshi Sato, Jun Ichiro Hamada

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

A 63-year-old woman presented with dizziness followed by gait disturbance and loss of appetite. Magnetic resonance image (MRI) showed that a lesion located in the medulla oblongata, appearing as hyperintense on T2-weighted image and with slight enhancement area, appeared in the ventral aspect of the mass on T1-weighted MR imaging with gadolinium. It was diagnosed as high-grade brain-stem glioma and the patient underwent chemoradiotherapy. However, she died 18 days after treatment, and autopsy was performed. The pathological diagnosis was glioblastoma (GBM) with unmethylated O-6-methylguanine-DNA methyltransferase promoter and wild isocitrate dehydrogenase 1 gene. We report an extremely short clinical course of adult GBM in medulla oblongata with genetic analysis and present a review of the literature.

Original languageEnglish
Pages (from-to)175-179
Number of pages5
JournalBrain Tumor Pathology
Volume30
Issue number3
DOIs
Publication statusPublished - 2013 Jul
Externally publishedYes

Keywords

  • Adult
  • IDH-1
  • MGMT
  • Medulla oblongata
  • Primary glioblastoma

ASJC Scopus subject areas

  • Oncology
  • Clinical Neurology
  • Cancer Research

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  • Cite this

    Yoshikawa, A., Nakada, M., Watanabe, T., Hayashi, Y., Sabit, H., Kato, Y., Suzuki, S., Ooi, A., Sato, H., & Hamada, J. I. (2013). Progressive adult primary glioblastoma in the medulla oblongata with an unmethylated MGMT promoter and without an IDH mutation. Brain Tumor Pathology, 30(3), 175-179. https://doi.org/10.1007/s10014-012-0118-9