Progression-free survival and overall survival of patients with clear cell carcinoma of the ovary treated with paclitaxel-carboplatin or irinotecan-cisplatin: Retrospective analysis

Masashi Takano, Toru Sugiyama, Nobuo Yaegashi, Mitsuaki Suzuki, Hiroshi Tsuda, Satoru Sagae, Yasuhiro Udagawa, Kazuo Kuzuya, Junzo Kigawa, Satoshi Takeuchi, Hitoshi Tsuda, Takuya Moriya, Yoshihiro Kikuchi

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33 Citations (Scopus)

Abstract

Background. Irinotecan hydrochloride, a topoisomerase I inhibitor, has been preliminarily recognized as an effective agent against clear cell carcinoma of the ovary (CCC), but there are few clinical data. Our aim was to compare progression-free survival (PFS) between patients treated with irinotecan hydrochloride and cisplatin (CPT-P) and those with treated with paclitaxel and carboplatin (TC). Methods. One hundred and seventeen patients at International Federation of Gynecology and Obstetrics (FIGO) stages Ic (ascites/malignant washing) - IV were identified by scanning the medical records of ten Japanese hospitals. After complete surgical staging procedures including lymphadenectomy, 35 patients received CPT-P and 82 patients received TC. The PFS and overall survival of the two groups were compared using the Kaplan-Meier method. Results. There was no significant difference in median age, performance status, FIGO stage, rate of optimal cytoreduction, or follow-up period between the CPT-P and TC groups. Two-year and 5-year PFS was 48% and 40%, respectively, in the TC group and 55% and 55%, respectively, in the CPT-P group (P = 0.31). Multiple regression analysis revealed that only residual tumor was an independent prognostic factor for PFS (P < 0.01). Conclusion. CPT-P showed a potential therapeutic effect, at least no less than that of TC therapy. Although there was no significant survival benefit in the present retrospective analysis, we recommend that the CPT-P regimen be evaluated in a larger, prospective, clinical trial.

Original languageEnglish
Pages (from-to)256-260
Number of pages5
JournalInternational Journal of Clinical Oncology
Volume12
Issue number4
DOIs
Publication statusPublished - 2007 Aug 1

Keywords

  • Adjuvant chemotherapy
  • Clear cell carcinoma
  • Irinotecan
  • Ovarian cancer
  • Paclitaxel
  • Progression-free survival

ASJC Scopus subject areas

  • Surgery
  • Hematology
  • Oncology

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