Progress in the development of the DexAide right ventricular assist device

Kiyotaka Fukamachi, Yoshio Ootaki, David J. Horvath, Alex L. Massiello, Keiji Kamohara, Masatoshi Akiyama, Faruk Cingoz, Chiyo Ootaki, Michael W. Kopcak, Raymond Dessoffy, Jenny Liu, Ji Feng Chen, Qun Zhou, Stephen Benefit, Leonard A.R. Golding, Sue Alfini, David T. Rowe

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)

Abstract

The DexAide right ventricular assist device (RVAD) is an implantable centrifugal pump modified from the CorAide left ventricular assist device. As previously published, in vitro performance testing of the DexAide RVAD has met design criteria, and the nominal operating condition of 4 l/min and 20 mm Hg pressure rise was achieved at 2,000 rpm, with a power consumption of 1.9 watts. In vivo studies in 14 calves have demonstrated acceptable hemodynamic characteristics. The calf inflow cannula design is still evolving to minimize depositions on the cannula observed in most experiments. Fitting studies were performed in 5 cadavers and 2 patients to reconfigure the cannulae for use in humans. The design and development of external electronics have been completed for the stand-alone RVAD system, and verification tests are under way in preparation for preclinical tests. Work on the external electronics design for the biventricular assist system is ongoing.In conclusion, the initial in vitro and in vivo studies have demonstrated acceptable hemodynamic characteristics of the DexAide RVAD. The design and development of the external electronic components for the stand-alone RVAD system have been completed. The calf inflow cannula is being redesigned, and chronic in vivo tests are under way.

Original languageEnglish
Pages (from-to)630-633
Number of pages4
JournalASAIO Journal
Volume52
Issue number6
DOIs
Publication statusPublished - 2006 Nov
Externally publishedYes

ASJC Scopus subject areas

  • Biophysics
  • Bioengineering
  • Biomaterials
  • Biomedical Engineering

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