TY - JOUR
T1 - Prognostic value of volumetric FDG PET/CT parameters in patients with oral tongue squamous cell carcinoma who were treated by superselective intra-arterial chemoradiotherapy
AU - Suzuki-Shibata, Satoko
AU - Yamamoto, Yayoi
AU - Yoshida, Tetsuo
AU - Mizoguchi, Nobutaka
AU - Nonaka, Tetsuo
AU - Kubota, Akira
AU - Narimatsu, Hiroto
AU - Miyagi, Yohei
AU - Kobayashi, Toshiaki
AU - Kaneta, Tomohiro
AU - Inoue, Tomio
N1 - Funding Information:
Acknowledgements This study was supported by the Kanagawa Cancer Center Collaborative Project between Hospital and Research Institute.
Publisher Copyright:
© 2017, Japan Radiological Society.
PY - 2017/12/1
Y1 - 2017/12/1
N2 - Purpose: This study aimed to evaluate the predictive and prognostic value of FDG PET/CT-based volumetric parameters in patients with oral tongue squamous cell carcinoma (OTSCC) treated by superselective intra-arterial chemoradiotherapy (IA-CRT). Methods: We conducted a retrospective study including 33 patients with biopsy-proven OTSCC between May 2007 and February 2016. All of the patients were treated by IA-CRT. Pretreatment SUVmax and metabolic tumor volume (MTV) of the primary tumor were measured. The SUV thresholds of 2.5 and 5.0 were used. Progression-free survival (PFS) and overall survival (OS) were chosen as endpoints to evaluate prognosis. Univariate and multivariate analyses were performed to assess the potential independent effect of FDG PET/CT parameters. Results: The median follow-up for surviving patients was 40.7 months (range 6.0–107.5 months). In univariate and multivariate analyses, SUVmax and MTV (5.0) were independent prognostic factors for PFS. In univariate analysis, SUVmax failed to predict OS. MTV (5.0) was a significant prognostic factor for OS, but multivariate analysis failed to show statistical independence because it could not exclude the possibility of an artifact due to N stage. Conclusions: FDG PET/CT-based volumetric parameters may be significant prognostic markers for survival of patients with OTSCC who are treated by IA-CRT.
AB - Purpose: This study aimed to evaluate the predictive and prognostic value of FDG PET/CT-based volumetric parameters in patients with oral tongue squamous cell carcinoma (OTSCC) treated by superselective intra-arterial chemoradiotherapy (IA-CRT). Methods: We conducted a retrospective study including 33 patients with biopsy-proven OTSCC between May 2007 and February 2016. All of the patients were treated by IA-CRT. Pretreatment SUVmax and metabolic tumor volume (MTV) of the primary tumor were measured. The SUV thresholds of 2.5 and 5.0 were used. Progression-free survival (PFS) and overall survival (OS) were chosen as endpoints to evaluate prognosis. Univariate and multivariate analyses were performed to assess the potential independent effect of FDG PET/CT parameters. Results: The median follow-up for surviving patients was 40.7 months (range 6.0–107.5 months). In univariate and multivariate analyses, SUVmax and MTV (5.0) were independent prognostic factors for PFS. In univariate analysis, SUVmax failed to predict OS. MTV (5.0) was a significant prognostic factor for OS, but multivariate analysis failed to show statistical independence because it could not exclude the possibility of an artifact due to N stage. Conclusions: FDG PET/CT-based volumetric parameters may be significant prognostic markers for survival of patients with OTSCC who are treated by IA-CRT.
KW - FDG PET/CT
KW - Metabolic tumor volume
KW - Oral tongue squamous cell carcinoma
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U2 - 10.1007/s11604-017-0686-z
DO - 10.1007/s11604-017-0686-z
M3 - Article
C2 - 29039110
AN - SCOPUS:85031931866
SN - 1867-1071
VL - 35
SP - 740
EP - 747
JO - Japanese Journal of Radiology
JF - Japanese Journal of Radiology
IS - 12
ER -