Prognostic value of plasma brain natriuretic peptide combined with left ventricular dimensions in predicting sudden death of patients with chronic heart failure

Jun Watanabe, Nobuyuki Shiba, Tsuyoshi Shinozaki, Yoshito Koseki, Akihiko Karibe, Tatsuya Komaru, Masahito Miura, Mitsumasa Fukuchi, Kouhei Fukahori, Masahito Sakuma, Yutaka Kagaya, Kunio Shirato

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)

Abstract

Background: We evaluated a combined assessment of brain natriuretic peptide (BNP) with left ventricular dimensions as a prognostic marker for sudden death in patients with chronic heart failure (CHF). Ventricular dimensions and BNP are separately recognized as prognostic markers for sudden death in patients with CHF. Methods and Results: CHF patients at Stage C and B were registered for a prospective study. From the database, we analyzed 417 patients with coronary arterial disease (CAD) or primary/secondary dilated cardiomyopathy (DCM). Main effects of BNP, left ventricular ejection fraction (EF), LV diastolic dimension (LVDD), and interaction of BNP with the EF and LVDD were tested with Cox's proportional hazard model. BNP in sudden death patients was significantly higher than that in event-free patients. Although multivariate analysis revealed that BNP by itself was not an independent risk factor for sudden death after adjustments, it was revealed that BNP entered the model via interaction with EF as a risk factor associating with sudden death. On the other hand, BNP was an independent risk factor associating with heart failure events (death and hospitalization), and BNP did not enter the model via an interaction with EF. Conclusion: BNP by itself was an independent risk factor for the heart failure events, but not for sudden death in CHF patients of the present study. However, BNP should be important in predicting sudden death when measured with EF.

Original languageEnglish
Pages (from-to)50-55
Number of pages6
JournalJournal of Cardiac Failure
Volume11
Issue number1
DOIs
Publication statusPublished - 2005 Feb

Keywords

  • Brain natriuretic peptide
  • Chronic heart failure
  • Left ventricular dimensions
  • Sudden death

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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