Prognostic significance of morning surge in blood pressure: Which definition, which outcome?

Takayoshi Ohkubo, Hirohito Metoki, Yutaka Imai

Research output: Contribution to journalArticlepeer-review

18 Citations (Scopus)

Abstract

The prognostic significance of morning surge in blood pressure (BP) remains obscure because the findings of the four prospective studies available [ambulatory BP monitoring (ABPM) substudy of the Syst-Eur trial, the Jichii Medical School ABPM-wave1 study, the Bordeaux hypertensive cohort study, and the Ohasama study] have generated conflicting results partly because of small number of events and differences in definitions, measurement conditions, target outcomes, and study populations. A large morning surge was associated with a significantly lower risk of total cardiovascular events in the Syst-Eur study. On the contrary, a large morning surge was associated with a significantly higher risk of total stroke events in the Jichii Medical School ABPM-wave1 study, and of total cardiovascular events in the Bordeaux hypertensive cohort study. The Ohasama study found that a large morning surge was not associated with the risk of total stroke events, but rather with a significantly higher risk of cerebral hemorrhage. More prospective studies or metaanalyses are required to better elucidate the prognostic significance of the morning surge in BP. Blood Press Monit 13:161-162

Original languageEnglish
Pages (from-to)161-162
Number of pages2
JournalBlood pressure monitoring
Volume13
Issue number3
DOIs
Publication statusPublished - 2008 Jun

Keywords

  • Ambulatory
  • Blood pressure monitoring
  • Mortality
  • Observational study
  • Population
  • Stroke

ASJC Scopus subject areas

  • Internal Medicine
  • Cardiology and Cardiovascular Medicine
  • Assessment and Diagnosis
  • Advanced and Specialised Nursing

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