Prognostic significance of Ku70 protein expression in patients with advanced colorectal cancer

Yasuhiro Komuro, Toshiaki Watanabe, Yoshio Hosoi, Yoshihisa Matsumoto, Keiichi Nakagawa, Norio Suzuki, Hirokazu Nagawa

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

Background/Aims: Ku protein stimulates DNA repair and signals the damage/stress responses, which may affect apoptosis and cell proliferation. The expression of Ku70 has been reported to be related to cell proliferation in a human gastric cancer cell line. However, in colorectal carcinoma, the clinical significance of Ku70 expression remains unclear. We examined the expression pattern of Ku70 in sporadic colorectal cancer and its relation to clinicopathological parameters and survival. Methodology: We studied 101 consecutive cases of advanced colorectal carcinoma. In resected specimens, the number of cells stained positive for Ku70 protein was evaluated by immunohistochemistry. Results: The percentage of cells expressing Ku70 in different tumors ranged from 4.2-99.7%. The elevated Ku70 expression group comprised 52 of 101 cases (52%). No significant correlation was seen between Ku expression pattern and the clinical parameters except depth of invasion. pTNM stage, histopathological grade and Ku70 were significant variables for prognosis of survival in the multivariate analysis. Conclusions: This is the first report correlating reduced survival with elevated expression of Ku protein in colorectal adenocarcinoma. Ku may be a new prognostic marker useful for selecting adjuvant treatment strategies.

Original languageEnglish
Pages (from-to)995-998
Number of pages4
JournalHepato-Gastroenterology
Volume52
Issue number64
Publication statusPublished - 2005 Jul

Keywords

  • Colorectal carcinoma
  • Immunohistochemistry
  • Ku70
  • Survival

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

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