Prognostic significance of insulin-like growth factor binding protein (IGF BP)-4 and IGF BP-5 expression in breast cancer

Keiko Mita, Zhenhuan Zhang, Yoshiaki Ando, Tatsuya Toyama, Maho Hamaguchi, Shunzo Kobayashi, Shin Ichi Hayashi, Yoshitaka Fujii, Hirotaka Iwase, Hiroko Yamashita

Research output: Contribution to journalArticlepeer-review

42 Citations (Scopus)

Abstract

Background: Expression of estrogen-regulated genes has been considered as potential predictive markers for endocrine therapy. We focused on two insulin-like growth factor binding proteins (IGFBPs): IGF BP-4, which is an early-responsive estrogen-induced gene, and IGF BP-5, which is an estrogen-repressed gene. Investigation of IGF BP-4 and IGF BP-5 expression would provide important information for predicting prognosis and endocrine responsiveness. Methods: The levels of IGF BP-4 and IGF BP-5 mRNA expression in 162 human breast cancer tissues were analyzed using quantitative real-time reverse transcriptase-PCR. The association between IGF BP-4 and IGF BP-5 expression and clinicopathological factors was then analyzed. Results The levels of IGF BP-4 and IGF BP-5 mRNA expression were positively correlated with estrogen receptor (ER) and progesterone receptor (PgR) status and were negatively correlated with HER2 overexpression. Patients with a high level of IGF BP-4 mRNA expression had better disease-free and overall survival than those with a low expression. Multivariate analysis showed that IGF BP-4 mRNA expression is an independent prognostic factor for disease-free survival. When analyzed in 116 patients with ER-positive breast cancer, patients whose tumor expressed higher levels of IGF BP-4 mRNA or lower levels of IGF BP-5 mRNA had better disease-free survival. Conclusion: IGF BP-4 mRNA expression was an independent prognostic factor in breast cancer, and patients with ER-positive breast cancer whose tumor expressed higher levels of IGF BP-4 and lower levels of IGF BP-5 had a better prognosis than those without such findings.

Original languageEnglish
Pages (from-to)575-582
Number of pages8
JournalJapanese journal of clinical oncology
Volume37
Issue number8
DOIs
Publication statusPublished - 2007 Aug

Keywords

  • Breast cancer
  • IGFBP-4
  • IGFBP-5
  • Prognosis

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Cancer Research

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