Prognostic impacts of metabolic syndrome in patients with chronic heart failure– A multicenter prospective cohort study –

Soichiro Tadaki, Yasuhiko Sakata, Yutaka Miura, Satoshi Miyata, Masanori Asakura, Kazunori Shimada, Takeshi Yamamoto, Yoshihiro Fukumoto, Toshiaki Kadokami, Satoshi Yasuda, Toshiro Miura, Shin Ichi Ando, Masafumi Yano, Masafumi Kitakaze, Hiroyuki Daida, Hiroaki Shimokawa

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

Background: Metabolic syndrome (MetS) is involved in the increased risk of atherosclerotic cardiovascular diseases. We have previously reported that the prevalence of MetS is more than 2-fold greater in patients with chronic heart failure (CHF) than in the general population in Japan. However, the prognostic impact of MetS in CHF patients remains to be elucidated. Methods and Results: In the present nationwide, large-scale clinical study in Japan, we enrolled 4,762 patients with Stage C/D CHF. The prevalence of MetS by the definition of the Japanese Committee for the Diagnostic Criteria in 2005 was 41.3% (50.6% in males, 21.5% in females). MetS was characterized by higher prevalence of males, obesity and lifestyle-related comorbidities, including glucose intolerance, dyslipidemia and hypertension. Multivariate Cox hazard analysis showed that MetS was associated with increased incidence of the composite of all-cause death and atherosclerotic events in males (hazard ratio [HR] 1.28; 95% confidence interval [CI] 1.06–1.54, P=0.011) but not in females (HR 1.23, 95% CI 0.87–1.75, P=0.241). Among the components of MetS, over waist circumference and glucose intolerance were significantly associated with increased incidence of the composite endpoint (HR 1.23, P=0.038, and HR 1.29, P<0.001, respectively) in males but not in females. Conclusions: The results indicate that MetS only has a negative prognostic impact in male CHF patients.

Original languageEnglish
Pages (from-to)677-688
Number of pages12
JournalCirculation Journal
Volume80
Issue number3
DOIs
Publication statusPublished - 2016 Feb 25
Externally publishedYes

Keywords

  • Chronic heart failure
  • Metabolic syndrome
  • Obesity
  • Prognosis
  • Sex differences

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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