Prognostic factors for survival after salvage surgery for locoregional recurrence of colon cancer

Takashi Akiyoshi, Yoshiya Fujimoto, Tsuyoshi Konishi, Hiroya Kuroyanagi, Masashi Ueno, Masatoshi Oya, Satoshi Miyata, Toshiharu Yamaguchi

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)

Abstract

Background: Although locoregional recurrence after rectal cancer resection has been extensively investigated, studies of salvage surgery for locoregionally recurrent colon cancer are scarce. This study aimed to determine the predictors of postsalvage survival for locoregionally recurrent colon cancer. Methods: We studied 45 consecutive patients who underwent macroscopically complete resection of locoregionally recurrent colon cancer between April 1988 and December 2007. The primary end point was cancer-specific survival, and 20 clinical variables were analyzed for their prognostic significance. Results: Cancer-specific 5-year survival for the entire cohort of 45 patients was 46%. Multivariate survival analysis showed that margin status (P =.0311), number of locoregional recurrent tumors (P =.0002), pathological grade (P =.0416), largest tumor diameter (P =.0247), and distant metastasis (P =.0006) were independently associated with cancer-specific survival. Conclusions: Salvage surgery for locoregional recurrence of colon cancer can provide a chance for long-term survival in selected patients.

Original languageEnglish
Pages (from-to)726-733
Number of pages8
JournalAmerican Journal of Surgery
Volume201
Issue number6
DOIs
Publication statusPublished - 2011 Jun

Keywords

  • Colon cancer
  • Locoregional recurrence
  • Prognostic factor
  • Salvage surgery

ASJC Scopus subject areas

  • Surgery

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