Prognosis of Japanese metastatic renal cell carcinoma patients in the targeted therapy era

Sei Naito, Tomoyuki Kato, Kazuyuki Numakura, Shingo Hatakeyama, Tomoyuki Koguchi, Shuya Kandori, Yoshihide Kawasaki, Hisanobu Adachi, Renpei Kato, Shintaro Narita, Hayato Yamamoto, Soichiro Ogawa, Sadafumi Kawamura, Wataru Obara, Akihiro Ito, Hiroyuki Nishiyama, Yoshiyuki Kojima, Chikara Ohyama, Tomonori Habuchi, Norihiko Tsuchiya

Research output: Contribution to journalArticlepeer-review

Abstract

Background: The aims of this study were to investigate prognosis and validate prognostic models [Memorial Sloan-Kettering Cancer Center (MSKCC), International Metastatic Renal Cell Carcinoma Data Consortium (IMDC), and Japanese metastatic renal cancer (JMRC) models] in the targeted therapy era in Japanese patients with metastatic renal cell carcinoma. Methods: We retrospectively analyzed 692 patients who were diagnosed with mRCC from January 2008 to August 2018 in the Michinoku Japan Urological Cancer Study Group database. Nivolumab as sequential therapy was widely used. Other immune checkpoint inhibitors were excluded from this study. Results: The median overall survival (95% confident interval) in all, MSKCC favorable, intermediate, and poor risk patients was 41.0 months (33.9–46.8), not reached (63.5 to not estimable), 46.8 months (37.1–52.9), and 10.4 months (8.9–14.4), respectively. The median overall survival (95% confident interval) in IMDC favorable, intermediate, and poor risk patients was not reached (61.6 to not estimable), 47.4 months (41.4–56.5), and 11.5 (9.9–16.3), respectively. The c-index of the MSKCC, IMDC, and JMRC models calculated at mRCC diagnosis was 0.680, 0.689, and 0.700, respectively. No statistical differences were found in the c-index among the models. Conclusion: While the real-world overall survival in Japanese patients with mRCC in the targeted therapy era improved compared to that previously reported in the cytokine era, there was no clear difference in the survival of poor risk patients between these eras. There were no differences in the superiority among the models.

Original languageEnglish
Pages (from-to)1947-1954
Number of pages8
JournalInternational Journal of Clinical Oncology
Volume26
Issue number10
DOIs
Publication statusPublished - 2021 Oct

Keywords

  • Metastatic renal cell carcinoma
  • Overall survival
  • Prognosis
  • Prognostic model
  • Targeted therapy

ASJC Scopus subject areas

  • Surgery
  • Hematology
  • Oncology

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