Prognosis of Chronic Glomerulonephritis: ‘Study on renal survival ratio of mesangial proliferative glomerulonephritis and membranoproliferative glomerulonephritis’

Takao Saito, Hiroshi Sato, Yasumichi Kinoshita, Jin Seino, Takashi Furuyama, Kaoru Yoshinaga

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

Renal survival curves for the adult patients at the ages between 15 and 60 with mesangial proliferative glomerulonephritis (MesPGN, N=366) and membranoproliferative glomerulonephritis (MPGN, N==76) were calculated using the method designed by Kaplan and Meier. In MesPGN, 80% and 68% of the patients survived 10 and 20 years after biopsy respectively; 88% and 72% survived 10 and 20 years after apparent onset. These results were similar to those analyzed by the research team “progressive renal lesions” in Ministry of Health and Welfare, Japan. When patients were histologically divided into 4 groups according to the index of glomerular lesions, %survival in each group was reduced in relation with the severity of the glomerular lesions, and there was significant difference between renal survival curves of each 2 groups. The influence of urinary protein and hypertension at the time of biopsy on survival curves was also significant. Patients with IgA nephropathy (N=74) showed the renal survival curve similar to those of MesPGN. The influence of hypertension on % survival was also significant in IgA nephropathy. In MPGN, 53% and 73% of patients survived 10 years after biopsy and apparent onset respectively. Therefore MPGN was poorer in prognosis than MesPGN. These results seem to be important as the controls when we try to study the long-term effects of various therapies against chronic glomerulonephritis.

Original languageEnglish
Pages (from-to)959-965
Number of pages7
JournalThe Japanese Journal Of Nephrology
Volume32
Issue number9
DOIs
Publication statusPublished - 1990 Jan

Keywords

  • Chronic glomerulonephritis
  • Hypertension
  • Membranoproliferative glomerulonephritis
  • Mesangial proliferative glomerulonephritis
  • Renal survival curve

ASJC Scopus subject areas

  • Nephrology

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