Prognosis of acute myeloid leukemia harboring monosomal karyotype in patients treated with or without allogeneic hematopoietic cell transplantation after achieving complete remission

Masamitsu Yanada, Saiko Kurosawa, Takuhiro Yamaguchi, Takuya Yamashita, Yukiyoshi Moriuchi, Hiroatsu Ago, Jin Takeuchi, Hirohisa Nakamae, Jun Taguchi, Toru Sakura, Yasushi Takamatsu, Fusako Waki, Hiroki Yokoyama, Masato Watanabe, Nobuhiko Emi, Takahiro Fukuda

Research output: Contribution to journalArticlepeer-review

24 Citations (Scopus)

Abstract

To evaluate the prognostic impact of monosomal karyotype on post-remission outcome in acute myeloid leukemia, we retrospectively analyzed 2,099 patients who had achieved complete remission. Monosomal karyotype was noted in 73 patients (4%). Of these, the probability of overall survival from first complete remission was 14% at four years, which was significantly lower than that reported in patients without monosomal karyotype, primarily due to a high relapse rate (86%). Monosomal karyotype remained significantly associated with worse overall survival among patients with unfavorable cytogenetics or complex karyotype, and even in patients who underwent allogeneic hematopoietic cell transplantation during first complete remission. These findings confirm that monosomal karyotype has a significantly adverse effect on post-remission outcome in patients with acute myeloid leukemia treated with and without allogeneic hematopoietic cell transplantation in first complete remission, emphasizing the need for the development of alternative therapies for this patient population.

Original languageEnglish
Pages (from-to)915-918
Number of pages4
JournalHaematologica
Volume97
Issue number6
DOIs
Publication statusPublished - 2012 Jun 1

Keywords

  • Acute myeloid leukemia
  • Allogeneic hematopoietic cell transplantation
  • Cytogenetics
  • Monosomal karyotype
  • Post-remission therapy

ASJC Scopus subject areas

  • Hematology

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