Progesterone receptor subtypes in vascular smooth muscle cells of human aorta

Yasuhiro Nakamura, Takashi Suzuki, Tsukasa Inoue, Chika Tazawa, Katsuhiko Ono, Takuya Moriya, Haruo Saito, Tadashi Ishibashi, Shoki Takahashi, Shogo Yamada, Hironobu Sasano

Research output: Contribution to journalArticlepeer-review

26 Citations (Scopus)

Abstract

Progesterone is involved in various functions of the cardiovascular system, including those of vascular smooth muscle cells (VSMCs) via progesterone receptor (PR). Progesterone has also been postulated to be involved in inhibition of VSMC proliferation via PR. However, the details of PR expression have remained largely unknown in human cardiovascular VSMCs. Therefore, we first examined the relative levels of PR isoform (PR-A and PR-B) expression in VSMCs, using both immunohistochemistry and quantitative RT-PCR analysis. PR-B was equally expressed between male and female aorta, but PR-A was more abundant in female than in male aorta. This finding demonstrated that the status of PR subtype expression was associated with the difference of genders.

Original languageEnglish
Pages (from-to)245-252
Number of pages8
Journalendocrine journal
Volume52
Issue number2
DOIs
Publication statusPublished - 2005 Apr

Keywords

  • Human aorta
  • Immunohistochemistry
  • Progesterone receptor
  • RT/real-time PCR
  • Vascular smooth muscle cells

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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