Profiles of tumor-infiltrating lymphocytes in a case of trichilemmal carcinoma with spontaneous regression

Sadanori Furudate, Taku Fujimura, Akira Tsukada, Yukikazu Numata, Yumi Kambayashi, Setsuya Aiba

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

We describe the case of a 69-year-old Japanese patient with spontaneous regression of trichilemmal carcinoma. We investigated the immunohistochemical profiles of tumor-infiltrating lymphocytes, focusing on cytotoxic granules, granulysin-bearing cells and immunosuppressive cells, such as regulatory T cells and tumor-associated macrophages. Our present study describes some of the possible mechanisms of the self-regression of cutaneous malignant tumors and potential therapies for trichilemmal carcinoma by modifying the tumor microenvironment.

Original languageEnglish
Pages (from-to)215-221
Number of pages7
JournalCase Reports in Dermatology
Volume4
Issue number3
DOIs
Publication statusPublished - 2012 Apr 20

Keywords

  • Granulysin
  • Spontaneous regression
  • Trichilemmal carcinoma

ASJC Scopus subject areas

  • Dermatology

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