Production of tetrodotoxin and its derivatives by Pseudomonas sp. isolated from the skin of a pufferfish

Mari Yotsu, Tomoko Yamazaki, Yuko Meguro, Amane Endo, Michio Murata, Hideo Naoki, Takeshi Yasumoto

Research output: Contribution to journalArticlepeer-review

115 Citations (Scopus)

Abstract

Bacteria isolated from the skin of the pufferfish Fugu poecilonotus were screened for tetrodotoxin production. Tetrodotoxin and its derivatives were detected by HPLC analyses in broth cultures of a Pseudomonas sp. Upon alkali treatment the compounds yielded, as do tetrodotoxin and its derivatives, 2-amino-6-hydroxymethyl-8-hydroxyquinazoline, the identity of which was confirmed, after methylation or trimethylsilylation, by HPLC, mass spectrometry and gas chromatography - mass spectrometry.

Original languageEnglish
Pages (from-to)225-228
Number of pages4
JournalToxicon
Volume25
Issue number2
DOIs
Publication statusPublished - 1987

ASJC Scopus subject areas

  • Toxicology

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