Production of [11C]cyanamide as a new precursor for [11C]benzylguanidine synthesis

Ren Iwata; Tatsuo Ido

doi:10.1016/0020-708X(83)90075-3

Production of [¹¹C]cyanamide as a new precursor for [¹¹C]benzylguanidine synthesis

Ren Iwata, Tatsuo Ido

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

A production method of [¹¹C]cyanamide as a new precursor for the synthesis of [¹¹C]guanidine derivatives has been developed. It was produced by the proton irradiation of calcium nitride and obtained in a calcium-free aqueous solution. Radiation effects were observed on the yield of [¹¹C]cyanamide. The maximum yield of about 30 mCi was obtained within 20 min after a 7 μA-30 min irradiation. As a typical synthesis application. [¹¹C]benzyguanidine was rapidly prepared by the reaction of [¹¹C]cyanamide with benzylamine. The overall radiochemical yield was about 20%, and the radiochemical purity was about 98%.

Original language	English
Pages (from-to)	973-976
Number of pages	4
Journal	The International Journal Of Applied Radiation And Isotopes
Volume	34
Issue number	7
DOIs	https://doi.org/10.1016/0020-708X(83)90075-3
Publication status	Published - 1983 Jul

ASJC Scopus subject areas

Radiation
Nuclear Energy and Engineering
Radiology Nuclear Medicine and imaging

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title = "Production of [11C]cyanamide as a new precursor for [11C]benzylguanidine synthesis",

abstract = "A production method of [11C]cyanamide as a new precursor for the synthesis of [11C]guanidine derivatives has been developed. It was produced by the proton irradiation of calcium nitride and obtained in a calcium-free aqueous solution. Radiation effects were observed on the yield of [11C]cyanamide. The maximum yield of about 30 mCi was obtained within 20 min after a 7 μA-30 min irradiation. As a typical synthesis application. [11C]benzyguanidine was rapidly prepared by the reaction of [11C]cyanamide with benzylamine. The overall radiochemical yield was about 20%, and the radiochemical purity was about 98%.",

author = "Ren Iwata and Tatsuo Ido",

year = "1983",

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T1 - Production of [11C]cyanamide as a new precursor for [11C]benzylguanidine synthesis

AU - Iwata, Ren

AU - Ido, Tatsuo

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N2 - A production method of [11C]cyanamide as a new precursor for the synthesis of [11C]guanidine derivatives has been developed. It was produced by the proton irradiation of calcium nitride and obtained in a calcium-free aqueous solution. Radiation effects were observed on the yield of [11C]cyanamide. The maximum yield of about 30 mCi was obtained within 20 min after a 7 μA-30 min irradiation. As a typical synthesis application. [11C]benzyguanidine was rapidly prepared by the reaction of [11C]cyanamide with benzylamine. The overall radiochemical yield was about 20%, and the radiochemical purity was about 98%.

AB - A production method of [11C]cyanamide as a new precursor for the synthesis of [11C]guanidine derivatives has been developed. It was produced by the proton irradiation of calcium nitride and obtained in a calcium-free aqueous solution. Radiation effects were observed on the yield of [11C]cyanamide. The maximum yield of about 30 mCi was obtained within 20 min after a 7 μA-30 min irradiation. As a typical synthesis application. [11C]benzyguanidine was rapidly prepared by the reaction of [11C]cyanamide with benzylamine. The overall radiochemical yield was about 20%, and the radiochemical purity was about 98%.

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