Production of [11C]cyanamide as a new precursor for [11C]benzylguanidine synthesis

Ren Iwata, Tatsuo Ido

    Research output: Contribution to journalArticlepeer-review

    10 Citations (Scopus)

    Abstract

    A production method of [11C]cyanamide as a new precursor for the synthesis of [11C]guanidine derivatives has been developed. It was produced by the proton irradiation of calcium nitride and obtained in a calcium-free aqueous solution. Radiation effects were observed on the yield of [11C]cyanamide. The maximum yield of about 30 mCi was obtained within 20 min after a 7 μA-30 min irradiation. As a typical synthesis application. [11C]benzyguanidine was rapidly prepared by the reaction of [11C]cyanamide with benzylamine. The overall radiochemical yield was about 20%, and the radiochemical purity was about 98%.

    Original languageEnglish
    Pages (from-to)973-976
    Number of pages4
    JournalThe International Journal Of Applied Radiation And Isotopes
    Volume34
    Issue number7
    DOIs
    Publication statusPublished - 1983 Jul

    ASJC Scopus subject areas

    • Radiation
    • Nuclear Energy and Engineering
    • Radiology Nuclear Medicine and imaging

    Fingerprint Dive into the research topics of 'Production of [<sup>11</sup>C]cyanamide as a new precursor for [<sup>11</sup>C]benzylguanidine synthesis'. Together they form a unique fingerprint.

    Cite this