TY - JOUR
T1 - Production of [11C]cyanamide as a new precursor for [11C]benzylguanidine synthesis
AU - Iwata, Ren
AU - Ido, Tatsuo
N1 - Funding Information:
Acknowledgements-Thaeu thorsw ish to thank Professor M. Fujioka and the cyclotron crew for carryingo ut the irradiations.T he presenti nvestigationw as partially supported by a Grant for ScientificR esearchN o. 57740308, Ministry of Education,S ciencea nd Culture,J apan.
Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.
PY - 1983/7
Y1 - 1983/7
N2 - A production method of [11C]cyanamide as a new precursor for the synthesis of [11C]guanidine derivatives has been developed. It was produced by the proton irradiation of calcium nitride and obtained in a calcium-free aqueous solution. Radiation effects were observed on the yield of [11C]cyanamide. The maximum yield of about 30 mCi was obtained within 20 min after a 7 μA-30 min irradiation. As a typical synthesis application. [11C]benzyguanidine was rapidly prepared by the reaction of [11C]cyanamide with benzylamine. The overall radiochemical yield was about 20%, and the radiochemical purity was about 98%.
AB - A production method of [11C]cyanamide as a new precursor for the synthesis of [11C]guanidine derivatives has been developed. It was produced by the proton irradiation of calcium nitride and obtained in a calcium-free aqueous solution. Radiation effects were observed on the yield of [11C]cyanamide. The maximum yield of about 30 mCi was obtained within 20 min after a 7 μA-30 min irradiation. As a typical synthesis application. [11C]benzyguanidine was rapidly prepared by the reaction of [11C]cyanamide with benzylamine. The overall radiochemical yield was about 20%, and the radiochemical purity was about 98%.
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U2 - 10.1016/0020-708X(83)90075-3
DO - 10.1016/0020-708X(83)90075-3
M3 - Article
AN - SCOPUS:0020964697
VL - 34
SP - 973
EP - 976
JO - Applied Radiation and Isotopes
JF - Applied Radiation and Isotopes
SN - 0969-8043
IS - 7
ER -