Abstract
A production method of [11C]cyanamide as a new precursor for the synthesis of [11C]guanidine derivatives has been developed. It was produced by the proton irradiation of calcium nitride and obtained in a calcium-free aqueous solution. Radiation effects were observed on the yield of [11C]cyanamide. The maximum yield of about 30 mCi was obtained within 20 min after a 7 μA-30 min irradiation. As a typical synthesis application. [11C]benzyguanidine was rapidly prepared by the reaction of [11C]cyanamide with benzylamine. The overall radiochemical yield was about 20%, and the radiochemical purity was about 98%.
Original language | English |
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Pages (from-to) | 973-976 |
Number of pages | 4 |
Journal | The International Journal Of Applied Radiation And Isotopes |
Volume | 34 |
Issue number | 7 |
DOIs | |
Publication status | Published - 1983 Jul |
ASJC Scopus subject areas
- Radiation
- Nuclear Energy and Engineering
- Radiology Nuclear Medicine and imaging