A production method of [11C]cyanamide as a new precursor for the synthesis of [11C]guanidine derivatives has been developed. It was produced by the proton irradiation of calcium nitride and obtained in a calcium-free aqueous solution. Radiation effects were observed on the yield of [11C]cyanamide. The maximum yield of about 30 mCi was obtained within 20 min after a 7 μA-30 min irradiation. As a typical synthesis application. [11C]benzyguanidine was rapidly prepared by the reaction of [11C]cyanamide with benzylamine. The overall radiochemical yield was about 20%, and the radiochemical purity was about 98%.
|Number of pages||4|
|Journal||The International Journal Of Applied Radiation And Isotopes|
|Publication status||Published - 1983 Jul|
ASJC Scopus subject areas
- Nuclear Energy and Engineering
- Radiology Nuclear Medicine and imaging