Production of parathyroid hormone-related protein by cultured human myeloma cells

A. Suzuki, T. Takahashi, Y. Okuno, R. Tsuyuoka, Y. Sasaki, M. Fukumoto, H. Katakami, K. Kita, T. Shibuya

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26 Citations (Scopus)

Abstract

We examined whether or not parathyroid hormone-related protein (PTH-rP) is produced in cultured human myeloma cells. PTH-rP protein was detected in the cell extract of one (U266) of 6 myeloma cell lines examined by radioimmunoassay. Also we demonstrated the expression of PTH-rP mRNA in all of the 6 lines. These findings indicate that PTH-rP may be one of the factors responsible for the bone destruction or hypercalcemia in multiple myeloma.

Original languageEnglish
Pages (from-to)88-90
Number of pages3
JournalAmerican Journal of Hematology
Volume45
Issue number1
DOIs
Publication statusPublished - 1994
Externally publishedYes

Keywords

  • hypercalcemia
  • multiple myeloma
  • PTH-rP

ASJC Scopus subject areas

  • Hematology

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  • Cite this

    Suzuki, A., Takahashi, T., Okuno, Y., Tsuyuoka, R., Sasaki, Y., Fukumoto, M., Katakami, H., Kita, K., & Shibuya, T. (1994). Production of parathyroid hormone-related protein by cultured human myeloma cells. American Journal of Hematology, 45(1), 88-90. https://doi.org/10.1002/ajh.2830450115