Production of parathyroid hormone-related protein by cultured human myeloma cells

A. Suzuki, T. Takahashi, Y. Okuno, R. Tsuyuoka, Y. Sasaki, M. Fukumoto, H. Katakami, K. Kita, T. Shibuya

Research output: Contribution to journalArticlepeer-review

26 Citations (Scopus)


We examined whether or not parathyroid hormone-related protein (PTH-rP) is produced in cultured human myeloma cells. PTH-rP protein was detected in the cell extract of one (U266) of 6 myeloma cell lines examined by radioimmunoassay. Also we demonstrated the expression of PTH-rP mRNA in all of the 6 lines. These findings indicate that PTH-rP may be one of the factors responsible for the bone destruction or hypercalcemia in multiple myeloma.

Original languageEnglish
Pages (from-to)88-90
Number of pages3
JournalAmerican Journal of Hematology
Issue number1
Publication statusPublished - 1994
Externally publishedYes


  • hypercalcemia
  • multiple myeloma
  • PTH-rP

ASJC Scopus subject areas

  • Hematology

Fingerprint Dive into the research topics of 'Production of parathyroid hormone-related protein by cultured human myeloma cells'. Together they form a unique fingerprint.

Cite this