Production of novel bispyrone metabolites in the cellular slime mold Dictyostelium giganteum induced by zinc(II) ion

Van Hai Nguyen, Haruhisa Kikuchi, Hiraku Sasaki, Kyoichi Iizumi, Yuzuru Kubohara, Yoshiteru Oshima

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

In this study, Zn2+induced the production of two new bispyrone-type metabolites, dictyobispyrone B and E, in the cellular slime mold Dictyostelium giganteum. Their structures were proposed on the basis of spectroscopic analysis and confirmed by chemical synthesis. They possess a novel α,α-bispyrone skeleton modified with long carbon chains. Both could be formed from two different polyketide chains through a novel biosynthetic pathway. Our results indicate that cultivation of cellular slime molds in the presence of Zn2+is a useful technique for discovering other structurally unique compounds.

Original languageEnglish
Pages (from-to)583-588
Number of pages6
JournalTetrahedron
Volume73
Issue number5
DOIs
Publication statusPublished - 2017 Jan 1

Keywords

  • Bispyrone
  • Cellular slime molds
  • Dictyostelium
  • Structural elucidation

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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