Production of nerve growth factor in rat skeletal muscle

Takehiko Amano; Tohru Yamakuni; Noriko Okabe; Kenji Sakimura; Yasuo Takahashi

doi:10.1016/0304-3940(91)90418-S

Production of nerve growth factor in rat skeletal muscle

Takehiko Amano, Tohru Yamakuni, Noriko Okabe, Kenji Sakimura, Yasuo Takahashi

PHA - Life and Pharmaceutical Science

Research output: Contribution to journal › Article › peer-review

58 Citations (Scopus)

Abstract

Production of the nerve growth factor (NGF) was confirmed by Northern blot hybridization using a specific probe of synthetic cDNA. In normal rat skeletal muscle, this probe clearly showed a band equivalent to 1.3 kilobases (kb) of messenger RNA (mRNA) of NGF of male mouse submaxillary gland. By denervation, the density of the bands derived from muscles increased by a factor of more than 3 at 4 and 6 days later compared to the control. The synthesis of mRNA of NGF in muscle was also confirmed following tetrodotoxin (TTX) blockade of sciatic nerve without denervation.

Original language	English
Pages (from-to)	5-7
Number of pages	3
Journal	Neuroscience Letters
Volume	132
Issue number	1
DOIs	https://doi.org/10.1016/0304-3940(91)90418-S
Publication status	Published - 1991 Oct 28

Keywords

Nerve growth factor
Skeletal muscle
mRNA

ASJC Scopus subject areas

Neuroscience(all)

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10.1016/0304-3940(91)90418-S

Cite this

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AU - Amano, Takehiko

AU - Yamakuni, Tohru

AU - Okabe, Noriko

AU - Sakimura, Kenji

AU - Takahashi, Yasuo

PY - 1991/10/28

Y1 - 1991/10/28

N2 - Production of the nerve growth factor (NGF) was confirmed by Northern blot hybridization using a specific probe of synthetic cDNA. In normal rat skeletal muscle, this probe clearly showed a band equivalent to 1.3 kilobases (kb) of messenger RNA (mRNA) of NGF of male mouse submaxillary gland. By denervation, the density of the bands derived from muscles increased by a factor of more than 3 at 4 and 6 days later compared to the control. The synthesis of mRNA of NGF in muscle was also confirmed following tetrodotoxin (TTX) blockade of sciatic nerve without denervation.

AB - Production of the nerve growth factor (NGF) was confirmed by Northern blot hybridization using a specific probe of synthetic cDNA. In normal rat skeletal muscle, this probe clearly showed a band equivalent to 1.3 kilobases (kb) of messenger RNA (mRNA) of NGF of male mouse submaxillary gland. By denervation, the density of the bands derived from muscles increased by a factor of more than 3 at 4 and 6 days later compared to the control. The synthesis of mRNA of NGF in muscle was also confirmed following tetrodotoxin (TTX) blockade of sciatic nerve without denervation.

KW - Nerve growth factor

KW - Skeletal muscle

KW - mRNA

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Production of nerve growth factor in rat skeletal muscle

Abstract

Keywords

ASJC Scopus subject areas

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