Production of nerve growth factor in rat skeletal muscle

Takehiko Amano, Tohru Yamakuni, Noriko Okabe, Kenji Sakimura, Yasuo Takahashi

Research output: Contribution to journalArticlepeer-review

56 Citations (Scopus)

Abstract

Production of the nerve growth factor (NGF) was confirmed by Northern blot hybridization using a specific probe of synthetic cDNA. In normal rat skeletal muscle, this probe clearly showed a band equivalent to 1.3 kilobases (kb) of messenger RNA (mRNA) of NGF of male mouse submaxillary gland. By denervation, the density of the bands derived from muscles increased by a factor of more than 3 at 4 and 6 days later compared to the control. The synthesis of mRNA of NGF in muscle was also confirmed following tetrodotoxin (TTX) blockade of sciatic nerve without denervation.

Original languageEnglish
Pages (from-to)5-7
Number of pages3
JournalNeuroscience Letters
Volume132
Issue number1
DOIs
Publication statusPublished - 1991 Oct 28

Keywords

  • Nerve growth factor
  • Skeletal muscle
  • mRNA

ASJC Scopus subject areas

  • Neuroscience(all)

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