Abstract
Production of the nerve growth factor (NGF) was confirmed by Northern blot hybridization using a specific probe of synthetic cDNA. In normal rat skeletal muscle, this probe clearly showed a band equivalent to 1.3 kilobases (kb) of messenger RNA (mRNA) of NGF of male mouse submaxillary gland. By denervation, the density of the bands derived from muscles increased by a factor of more than 3 at 4 and 6 days later compared to the control. The synthesis of mRNA of NGF in muscle was also confirmed following tetrodotoxin (TTX) blockade of sciatic nerve without denervation.
Original language | English |
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Pages (from-to) | 5-7 |
Number of pages | 3 |
Journal | Neuroscience Letters |
Volume | 132 |
Issue number | 1 |
DOIs | |
Publication status | Published - 1991 Oct 28 |
Keywords
- Nerve growth factor
- Skeletal muscle
- mRNA
ASJC Scopus subject areas
- Neuroscience(all)