TY - JOUR
T1 - Production of Complete Heart Block and Utero Cardiac Pacing in Fetal Lambs
AU - Murotsuki, Jun
AU - Okamura, Kunihiro
AU - Watanabe, Takanori
AU - Kimura, Yoshitaka
AU - Yajima, Akira
PY - 1995/1/1
Y1 - 1995/1/1
N2 - We produced a complete heart block in 5 fetal lambs at 120 to 135 days of gestation by injecting 10% formaldehyde into the His bundle. We obtained acute experimental data in 5 fetuses and chronic experimental data in 2 fetuses. Immediately after production of the complete heart block, cardiac output was acutely reduced to 43 ± 9% when compared with the cardiac output at sinus rhythm. It was possible to restore the cardiac output to 80 ± 7% of the preoperative levels by atrioventricular pacing at the same rate as had been present before the heart block was produced. When the heart rate decreased below 100 beats per minute, further increase of stroke volume did not occur, and output was markedly diminished. This model allows us to study the pathophysiological response of a complete heart block, and offers basic information useful for understanding fetal cardiac functioning.
AB - We produced a complete heart block in 5 fetal lambs at 120 to 135 days of gestation by injecting 10% formaldehyde into the His bundle. We obtained acute experimental data in 5 fetuses and chronic experimental data in 2 fetuses. Immediately after production of the complete heart block, cardiac output was acutely reduced to 43 ± 9% when compared with the cardiac output at sinus rhythm. It was possible to restore the cardiac output to 80 ± 7% of the preoperative levels by atrioventricular pacing at the same rate as had been present before the heart block was produced. When the heart rate decreased below 100 beats per minute, further increase of stroke volume did not occur, and output was markedly diminished. This model allows us to study the pathophysiological response of a complete heart block, and offers basic information useful for understanding fetal cardiac functioning.
KW - cardiac output
KW - complete heart block
KW - fetal cardiac pacing
KW - fetal lambs
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U2 - 10.1111/j.1447-0756.1995.tb01003.x
DO - 10.1111/j.1447-0756.1995.tb01003.x
M3 - Article
C2 - 8590359
AN - SCOPUS:0029077521
VL - 21
SP - 233
EP - 239
JO - Journal of Obstetrics and Gynaecology Research
JF - Journal of Obstetrics and Gynaecology Research
SN - 1341-8076
IS - 3
ER -