Probiotic bacteria stimulate gut epithelial cell proliferation in rat

Hirofumi Ichikawa, Toyoaki Kuroiwa, Akiko Inagaki, Ryuzaburo Shineha, Teturo Nishihira, Susumu Satomi, Takashi Sakata

Research output: Contribution to journalArticlepeer-review

103 Citations (Scopus)

Abstract

Probiotics are used for various intestinal diseases. However, their effects on gut epithelial cell proliferation have not been investigated. We administered 107 colony-forming units of Lactobacillus casei or Clostridium butyricum, or no probiotics (control) by gastric intubation once a day for seven days to rats fed an elemental diet. We estimated the crypt cell production rate of the jejunum, ileum, cecum, and distal colon. We also quantified cecal bacteria. Both probiotics increased the crypt cell production rate of the jejunum and ileum by 25-40%, of the cecum by 70%, and of the distal colon by more than 200% compared with control. Only minor variance in the cecal bacterial composition existed among the three groups. Probiotics enhanced gut epithelial cell proliferation in rats fed an elemental diet.

Original languageEnglish
Pages (from-to)2119-2123
Number of pages5
JournalDigestive Diseases and Sciences
Volume44
Issue number10
DOIs
Publication statusPublished - 1999 Nov 11

Keywords

  • Cell division
  • Clostridium
  • Intestine
  • Lactobacillus
  • Probiotics

ASJC Scopus subject areas

  • Physiology
  • Gastroenterology

Fingerprint Dive into the research topics of 'Probiotic bacteria stimulate gut epithelial cell proliferation in rat'. Together they form a unique fingerprint.

Cite this