Proanthocyanidin-rich grape seed extract prevent estrogen deficiency-induced metabolic disorders

Guangwen Jin, Alkebaier Aobulikasimu, Jinying Piao, Zulipiya Aibibula, Daisuke Koga, Hiroki Ochi, Kirika Ishiyama, Taro Kanno, Yoshimi Niwano, Atsushi Okawa, Yoshinori Asou

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)


The postmenopausal state is associated with an increased risk of metabolic syndrome. Grape seed extract (GSE), a rich source of proanthocyanidins, has beneficial effects on low-grade inflammatory diseases in a high-fat diet-induced obesity model and therefore is a candidate to improve postmenopausal metabolic abnormalities. In the present study, the effects of dietary GSE on body weight and glucose tolerance were examined in ovariectomized (OVX) mice. Female C57BL6/J mice underwent ovariectomy or a sham operation, and OVX mice were orally administered GSE (100 mg/ kg B.W.) or the vehicle solution (OVX+V). Mice in the OVX+V group weighed significantly more than mice in the Sham group. Body weight was significantly lower in the OVX+GSE group than in the OVX+V group. The weights of subcutaneous white adipose tissue (WAT) and visceral WAT were significantly lower in the OVX+GSE group than in the OVX+V group. In glucose tolerance tests, OVX+GSE mice showed significantly lower blood glucose levels at 30 min and 60 min than those in OVX+V mice. In conclusion, we demonstrated that GSE prevents metabolic disorders, such as obesity and glucose intolerance, in OVX mice. These results support the potential therapeutic applications of GSE in postmenopausal women.

Original languageEnglish
Pages (from-to)45-50
Number of pages6
JournalJournal of Medical and Dental Sciences
Issue number2
Publication statusPublished - 2018


  • Glucose tolerance
  • Obesity
  • Postmenopause
  • Proanthocyanidins

ASJC Scopus subject areas

  • Dentistry(all)


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