Prion diseases: Disease diversity and therapeutics

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Abstract

More than one hundred victims of iatrogenic CJD with cadaveric dura mater grafting have been recognized in Japan, and the people have been also exposed to a risk of outbreaks of variant CJD. These diseases are distinct from other forms of prion diseases as well as other neuropsychiatrie disorders, but on an early clinical stage, their differential diagnoses from other atypical forms of prion diseases are not necessarily easy. Thus, atypical forms of prion diseases were overviewed and discussed here. In addition, data on recent clinical trials of enteral antimalarial drug (quinacrine or quinine) treatment or intracerebroventricular pentosan polysulfate treatment were presented and discussed, because research progress in the therapeutics for prion diseases has been remarkably made on the basis of the prevalence of those acquired forms of prion diseases.

Original languageEnglish
Pages (from-to)855-856
Number of pages2
JournalClinical Neurology
Volume44
Issue number11
Publication statusPublished - 2004 Nov

Keywords

  • Antimalarial
  • Differential diagnosis
  • Pentosan polysulfate
  • Therapeutics
  • Variant CJD

ASJC Scopus subject areas

  • Clinical Neurology

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