Printed 3D Electrode Arrays with Micrometer-Scale Lateral Resolution for Extracellular Recording of Action Potentials

Leroy Grob, Hideaki Yamamoto, Sabine Zips, Philipp Rinklin, Ayumi Hirano-Iwata, Bernhard Wolfrum

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

Current investigations on neuronal or cardiac tissues call for systems that can electrically monitor cellular activity in three dimensions as opposed to classical planar approaches. Typically the fabrication of such 3D microelectrode arrays (3D MEAs) relies on advanced cleanroom fabrication techniques. However, additive manufacturing is becoming an ever versatile alternative for rapid prototyping of novel sensor designs due to its low cost and material expense. Here, the possibility of fabricating high-resolution 3D MEAs is demonstrated by using electrohydrodynamic inkjet printing. The height and aspect ratio of the 3D electrodes can be readily tuned by adjusting the printing conditions and number of deposited ink droplets per electrode. The fabrication of pillar electrode arrays with electrode diameters of sintered structures below 3 µm is shown. The functionality of the array is confirmed using impedance spectroscopy and extracellular recordings of action potentials from HL-1 cells.

Original languageEnglish
Article number1900517
JournalAdvanced Materials Technologies
Volume5
Issue number3
DOIs
Publication statusPublished - 2020 Mar 1

Keywords

  • 3D microelectrode arrays
  • additive manufacturing
  • bioelectronics
  • electrohydrodynamic inkjet printing
  • gold nanoparticles

ASJC Scopus subject areas

  • Materials Science(all)
  • Mechanics of Materials
  • Industrial and Manufacturing Engineering

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