Primary yolk sac tumor in the cerebellar vermis. case report

Taigen Nakamura, Masayuki Kanamori, Yukihiko Sonoda, Mika Watanabe, Toshihiro Kumabe, Teiji Tominaga

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

A 2-year-old boy presented with gait disturbance and limb ataxia. T1-weighted magnetic resonance (MR) imaging with gadolinium- diethylenetriaminepenta-acetic acid administration showed a heterogeneously enhanced mass lesion with a cystic component in the cerebellar vermis. The minimum apparent diffusion coefficient value of the lesion was 1.96 × 10 3- mm 2/sec, and H-MR spectroscopy showed elevated choline and lipid peaks, and decreased N-acetyl aspartate peak. The tumor was totally resected, and the histological diagnosis was yolk sac tumor. Consistent with this diagnosis, a-fetoprotein levels in the serum and cerebrospinal fluid were 7.094 ng/m/ and 22.3 ng/m/. respectively. 'F-fluorodeoxyglucose- positron emission tomography, and thoracic, abdominal, and pelvic computed tomography showed no abnormal lesions, excluding the possibility of metastatic yolk sac tumor from an extracranial lesion. The patient received chemotherapy consisting of ifosfamide. cisplatin, and etoposide, and had not relapsed at 6 months after resection. Germ cell tumors rarely develop in the posterior fossa. This case suggests that yolk sac tumor could develop in the cerebellar vermis.

Original languageEnglish
Pages (from-to)173-177
Number of pages5
JournalNeurological Surgery
Volume37
Issue number2
Publication statusPublished - 2009 Feb 1

Keywords

  • Cerebellar vermis
  • Germ cell tumor
  • Yolk sac tumor

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

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