Primary structure of Electrophorus electricus sodium channel deduced from cDNA sequence

Masaharu Noda, Shin Shimizu, Tsutomu Tanabe, Toshiyuki Takai, Toshiaki Kayano, Takayuki Ikeda, Hideo Takahashi, Hitoshi Nakayama, Yuichi Kanaoka, Naoto Minamino, Kenji Kangawa, Hisayuki Matsuo, Michael A. Raftery, Tadaaki Hirose, Seiichi Inayama, Hidenori Hayashida, Takashi Miyata, Shosaku Numa

Research output: Contribution to journalArticlepeer-review

978 Citations (Scopus)

Abstract

Cloning and sequence analysis of cDNA for the Electrophorus electricus electroplax sodium channel indicate that this protein, consisting of 1,820 amino acid residues, exhibits four repeated homology units, which are presumably oriented in a pseudosymmetric fashion across the membrane. Each homology unit contains a unique segment with clustered positively charged residues, which may be involved in the gating structure, possibly in conjunction with negatively charged residues clustered elsewhere.

Original languageEnglish
Pages (from-to)121-127
Number of pages7
JournalNature
Volume312
Issue number5990
DOIs
Publication statusPublished - 1984
Externally publishedYes

ASJC Scopus subject areas

  • General

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