Primary structure and functional expression from complementary DNA of a brain calcium channel

Yasuo Mori, Thomas Friedrich, Man Suk Kim, Atsushi Mikami, Junichi Nakai, Peter Ruth, Eva Bosse, Franz Hofmann, Veit Flockerzi, Teiichi Furuichi, Katsuhiko Mikoshiba, Keiji Imoto, Tsutomu Tanabe, Shosaku Numa

Research output: Contribution to journalArticlepeer-review

695 Citations (Scopus)

Abstract

The primary structure of a voltage-dependent cal-cium channel from rabbit brain has been deduced by cloning and sequencing the complementary DNA. Calcium channel activity expressed from the cDNA is dramatically increased by coexpression of the α2 and β subunits, known to be associated with the dihydropyridine receptor. This channel is a high voltage-activated calcium channel that is insensitive both to nifedipine and to ω-conotoxin. We suggest that it is expressed predominantly in cerebellar Purkinje cells and granule cells.

Original languageEnglish
Pages (from-to)398-402
Number of pages5
JournalNature
Volume350
Issue number6317
DOIs
Publication statusPublished - 1991 Jan 1
Externally publishedYes

ASJC Scopus subject areas

  • General

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