Primary structure and distribution of a novel ryanodine receptor/calcium release channel from rabbit brain

Yasuhiro Hakamata, Junichi Nakai, Hiroshi Takeshima, Keiji Imoto

Research output: Contribution to journalArticle

329 Citations (Scopus)

Abstract

The complete amino acid sequence of a novel ryanodine receptor/calcium release channel from rabbit brain has been deduced by cloning and sequence analysis of the EDNA. This protein is composed of 4872 amino acids and shares characteristic structural features with the skeletal muscle and cardiac ryanodine receptors. RNA blot hybridization analysis shows that the brain ryanodine receptor is abundantly expressed in corpus striatum, thalamus and hippocampus, whereas the cardiac ryanodine receptor is more uniformly expressed in the brain. The brain ryanodine receptor gene is transcribed also in smooth muscle.

Original languageEnglish
Pages (from-to)229-235
Number of pages7
JournalFEBS Letters
Volume312
Issue number2-3
DOIs
Publication statusPublished - 1992 Nov 9
Externally publishedYes

Keywords

  • Calcium release channel
  • RNA blot hybridization
  • Rabbit brain
  • Ryanodine receptor
  • Smooth muscle
  • cDNA cloning

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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