Primary retroperitoneal diffuse large B-cell lymphoma presenting with numb chin syndrome and painful ophthalmoplegia

Satoshi Ichikawa, Kei Saito, Takuma Suzuki, Jun Kimura, Hideo Harigae

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

Numb chin syndrome (NCS) and painful ophthalmoplegia (PO) are neurological syndromes associated with the disturbance of certain cranial nerves and their downstream nerves. These syndromes are caused by various diseases, and, in rare cases precede the diagnosis of systemic malignant lymphoma. We herein present the case of a 59-year-old man diagnosed simultaneously with NCS and PO caused by a tumor located around the cavernous sinus and with diffuse large B-cell lymphoma that was identified via biopsy of a large retroperitoneal tumor. He was successfully treated with a standard rituximab-containing chemotherapy combined with high-dose intravenous methotrexate and intrathecal chemotherapy.

Original languageEnglish
Pages (from-to)1813-1819
Number of pages7
JournalInternal Medicine
Volume52
Issue number16
DOIs
Publication statusPublished - 2013
Externally publishedYes

Keywords

  • Autologous peripheral blood stem cell transplantation
  • Central nervous system infiltration
  • Diffuse large B-cell lymphoma
  • Numb chin syndrome
  • Painful ophthalmoplegia
  • Primary retroperitoneal lymphoma

ASJC Scopus subject areas

  • Internal Medicine

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