TY - JOUR
T1 - Primary large cell carcinoma of the submandibular gland
AU - Ishikawa, Shuuji
AU - Nagata, Yasushi
AU - Mitsumori, Michihide
AU - Sasai, Keisuke
AU - Kokubo, Masaki
AU - Hiraoka, Masahiro
AU - Tanaka, Tomoyuki
AU - Fukumoto, Manabu
PY - 1999/6
Y1 - 1999/6
N2 - A rare case of primary large cell carcinoma of the submandibular gland is reported. A 53-year-old man presented with a tumor in the left submandibular region extending to the supraclavicular fossa. After unsuccessful radiochemotherapy at another hospital, he was referred to our department for combined therapy of radiation, hyperthermia, and intraarterial anticancer drug infusion. Although the local tumor decreased in size after therapy, the patient died of respiratory insufficiency due to rapid progression of pulmonary metastases. Autopsy showed that tumor cells in both the submandibular gland and the lung were compatible with undifferentiated large cell carcinoma without tubular formation or laminar structure. The submandibular tumor was considered to be the primary site because cicatricial tissue surrounding the lesion suggested that had formed over a long period. The pulmonary lesions were considered to be metastases because necrosis and intravascular carcinoma cell embolism were noted. The above findings led to the final diagnosis of primary large cell carcinoma of the submandibular gland with pulmonary metastases. This condition has rarely been reported in the literature.
AB - A rare case of primary large cell carcinoma of the submandibular gland is reported. A 53-year-old man presented with a tumor in the left submandibular region extending to the supraclavicular fossa. After unsuccessful radiochemotherapy at another hospital, he was referred to our department for combined therapy of radiation, hyperthermia, and intraarterial anticancer drug infusion. Although the local tumor decreased in size after therapy, the patient died of respiratory insufficiency due to rapid progression of pulmonary metastases. Autopsy showed that tumor cells in both the submandibular gland and the lung were compatible with undifferentiated large cell carcinoma without tubular formation or laminar structure. The submandibular tumor was considered to be the primary site because cicatricial tissue surrounding the lesion suggested that had formed over a long period. The pulmonary lesions were considered to be metastases because necrosis and intravascular carcinoma cell embolism were noted. The above findings led to the final diagnosis of primary large cell carcinoma of the submandibular gland with pulmonary metastases. This condition has rarely been reported in the literature.
KW - Carcinoma of the submandibular gland
KW - Hyperthermia
KW - Large cell carcinoma
KW - Radiation therapy
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U2 - 10.1007/s101470050052
DO - 10.1007/s101470050052
M3 - Article
AN - SCOPUS:0032814780
VL - 4
SP - 189
EP - 192
JO - International Journal of Clinical Oncology
JF - International Journal of Clinical Oncology
SN - 1341-9625
IS - 3
ER -