Primary biliary cirrhosis with antibody against carbonic anhydrase II associates with distinct immunological backgrounds

Yoshiyuki Ueno, Motoyasu Ishii, Takehiko Igarashi, Yutaka Mano, Kaichiro Yahagi, Norihiro Kisara, Yoshie Kobayashi, Hirofumi Niitsuma, Koju Kobayashi, Tooru Shimosegawa

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)

Abstract

Objective: a part of patients with primary biliary cirrhosis (PBC) has anti-human carbonic anhydrase II (CA II) autoantibodies, although several contradictional reports followed. Since immunization of mice with CA II results in cholangitis in a susceptible strain, PBC with anti-CA II antibody may have distinct clinical features. Thus, we tested the sera of patients with PBC for anti-CA II antibodies and compared clinical characteristics of PBC patients with and without anti-CA II antibodies in Japanese patients. Methods: anti-CA II antibodies were detected in nine of 50 (18%) PBC patients by immunoblotting. The evaluation of these patients included various clinical parameters, autoantibodies, and immunological backgrounds. Results: the levels of serum liver tests and the prevalence of serum anti-mitochondrial antibody (77.8 vs. 92.7%) were not different between the patients with and without anti-CA II antibody. However, the prevalence of anti-nuclear antibody (ANA) was significantly higher in the patients with anti-CA II antibody than that in the patients without anti-CA II antibody (66.7 vs. 25.6%, P = 0.044), although their mean titers were not statistically different. Association of Sjøgren's syndrome tended to be more frequent in the patients with anti-CA II antibody than those without it (33.3 vs. 14.6%, P = 0.327). Studies of HLA class I allotype revealed that three of five (60.0%) patients with anti-CA II antibodies and one patients from 34 (3.0%) patients without anti-CA II antibodies had HLA B51 allotype; the difference in the prevalence of this allotype was significant (P = 0.004, Pc = 0.01), and the prevalence of other HLA class I and HLA DR allotypes was similar between the patients with and those without anti-CA II antibody. Administration of ursodeoxycholic acid (600 mg per day) was accompanied by change in liver tests in a similar way between the two patient groups. Conclusions: These results suggest that, although clinical features are not distinctive, PBC patients with anti-CA II antibody may have a genetic background, which may contribute to a susceptibility to immune-mediated cholangitis.

Original languageEnglish
Pages (from-to)18-27
Number of pages10
JournalHepatology Research
Volume20
Issue number1
DOIs
Publication statusPublished - 2001

Keywords

  • Anti-mitochondrial autoantibodies
  • Carbonic anhydrase II
  • Primary biliary cirrhosis

ASJC Scopus subject areas

  • Hepatology
  • Infectious Diseases

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