Primary aldosteronism with bilateral multiple aldosterone-producing adrenal adenomas

Akira Matsuda; Mutsuo Beniko; Akemi Ikota; Masao Yamazaki; Shigeki Koizumi; Hiroaki Mizumoto; Takeo Watanabe; Kumiko Matsuya; Haruhiko Kunita; Yasuo Mashio; Hironobu Sasano

doi:10.2169/internalmedicine.35.970

Primary aldosteronism with bilateral multiple aldosterone-producing adrenal adenomas

Akira Matsuda, Mutsuo Beniko, Akemi Ikota, Masao Yamazaki, Shigeki Koizumi, Hiroaki Mizumoto, Takeo Watanabe, Kumiko Matsuya, Haruhiko Kunita, Yasuo Mashio, Hironobu Sasano

MED - Medical Sciences

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

A 41-year-old woman developed primary aldosteronism due to bilateral multiple aldosterone-producing adenomas (APA), She was suspected to have idiopathic hyperaldosferonism (IHA) 7 years previously. Although preoperative data suggested APA and IHA was suspected in a postoperative microscopic specimen, a definite clinical diagnosis could not be made. Cytochrome P-450 and other enzymes involved in aldosterone synthesis were found in the tumor portions but not in the zona glomerulosa of attached adrenals, which histopathologically showed "paradoxical hyperplasia". This was a rare case of bilateral multiple APA, which could be differentiated from IHA by immunohistochemical analysis of adrenal steroidogenic enzymes.

Original language	English
Pages (from-to)	970-975
Number of pages	6
Journal	Internal Medicine
Volume	35
Issue number	12
DOIs	https://doi.org/10.2169/internalmedicine.35.970
Publication status	Published - 1996 Dec

Keywords

Aldosterone-producing adenoma
Bilateral adrenocortical lesions
Steroidogenic enzymes

ASJC Scopus subject areas

Internal Medicine

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10.2169/internalmedicine.35.970

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Primary aldosteronism with bilateral multiple aldosterone-producing adrenal adenomas. / Matsuda, Akira; Beniko, Mutsuo; Ikota, Akemi; Yamazaki, Masao; Koizumi, Shigeki; Mizumoto, Hiroaki; Watanabe, Takeo; Matsuya, Kumiko; Kunita, Haruhiko; Mashio, Yasuo; Sasano, Hironobu.

In: Internal Medicine, Vol. 35, No. 12, 12.1996, p. 970-975.

Research output: Contribution to journal › Article › peer-review

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abstract = "A 41-year-old woman developed primary aldosteronism due to bilateral multiple aldosterone-producing adenomas (APA), She was suspected to have idiopathic hyperaldosferonism (IHA) 7 years previously. Although preoperative data suggested APA and IHA was suspected in a postoperative microscopic specimen, a definite clinical diagnosis could not be made. Cytochrome P-450 and other enzymes involved in aldosterone synthesis were found in the tumor portions but not in the zona glomerulosa of attached adrenals, which histopathologically showed {"}paradoxical hyperplasia{"}. This was a rare case of bilateral multiple APA, which could be differentiated from IHA by immunohistochemical analysis of adrenal steroidogenic enzymes.",

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AU - Matsuda, Akira

AU - Beniko, Mutsuo

AU - Ikota, Akemi

AU - Yamazaki, Masao

AU - Koizumi, Shigeki

AU - Mizumoto, Hiroaki

AU - Watanabe, Takeo

AU - Matsuya, Kumiko

AU - Kunita, Haruhiko

AU - Mashio, Yasuo

AU - Sasano, Hironobu

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N2 - A 41-year-old woman developed primary aldosteronism due to bilateral multiple aldosterone-producing adenomas (APA), She was suspected to have idiopathic hyperaldosferonism (IHA) 7 years previously. Although preoperative data suggested APA and IHA was suspected in a postoperative microscopic specimen, a definite clinical diagnosis could not be made. Cytochrome P-450 and other enzymes involved in aldosterone synthesis were found in the tumor portions but not in the zona glomerulosa of attached adrenals, which histopathologically showed "paradoxical hyperplasia". This was a rare case of bilateral multiple APA, which could be differentiated from IHA by immunohistochemical analysis of adrenal steroidogenic enzymes.

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Primary aldosteronism with bilateral multiple aldosterone-producing adrenal adenomas

Abstract

Keywords

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