Abstract
A 41-year-old woman developed primary aldosteronism due to bilateral multiple aldosterone-producing adenomas (APA), She was suspected to have idiopathic hyperaldosferonism (IHA) 7 years previously. Although preoperative data suggested APA and IHA was suspected in a postoperative microscopic specimen, a definite clinical diagnosis could not be made. Cytochrome P-450 and other enzymes involved in aldosterone synthesis were found in the tumor portions but not in the zona glomerulosa of attached adrenals, which histopathologically showed "paradoxical hyperplasia". This was a rare case of bilateral multiple APA, which could be differentiated from IHA by immunohistochemical analysis of adrenal steroidogenic enzymes.
Original language | English |
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Pages (from-to) | 970-975 |
Number of pages | 6 |
Journal | Internal Medicine |
Volume | 35 |
Issue number | 12 |
DOIs | |
Publication status | Published - 1996 Dec |
Keywords
- Aldosterone-producing adenoma
- Bilateral adrenocortical lesions
- Steroidogenic enzymes
ASJC Scopus subject areas
- Internal Medicine