Primary aldosteronism with bilateral multiple aldosterone-producing adrenal adenomas

Akira Matsuda; Mutsuo Beniko; Akemi Ikota; Masao Yamazaki; Shigeki Koizumi; Hiroaki Mizumoto; Takeo Watanabe; Kumiko Matsuya; Haruhiko Kunita; Yasuo Mashio; Hironobu Sasano

doi:10.2169/internalmedicine.35.970

Primary aldosteronism with bilateral multiple aldosterone-producing adrenal adenomas

Akira Matsuda, Mutsuo Beniko, Akemi Ikota, Masao Yamazaki, Shigeki Koizumi, Hiroaki Mizumoto, Takeo Watanabe, Kumiko Matsuya, Haruhiko Kunita, Yasuo Mashio, Hironobu Sasano

MED - Medical Sciences

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

A 41-year-old woman developed primary aldosteronism due to bilateral multiple aldosterone-producing adenomas (APA), She was suspected to have idiopathic hyperaldosferonism (IHA) 7 years previously. Although preoperative data suggested APA and IHA was suspected in a postoperative microscopic specimen, a definite clinical diagnosis could not be made. Cytochrome P-450 and other enzymes involved in aldosterone synthesis were found in the tumor portions but not in the zona glomerulosa of attached adrenals, which histopathologically showed "paradoxical hyperplasia". This was a rare case of bilateral multiple APA, which could be differentiated from IHA by immunohistochemical analysis of adrenal steroidogenic enzymes.

Original language	English
Pages (from-to)	970-975
Number of pages	6
Journal	Internal Medicine
Volume	35
Issue number	12
DOIs	https://doi.org/10.2169/internalmedicine.35.970
Publication status	Published - 1996 Dec

Keywords

Aldosterone-producing adenoma
Bilateral adrenocortical lesions
Steroidogenic enzymes

ASJC Scopus subject areas

Internal Medicine

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Primary aldosteronism with bilateral multiple aldosterone-producing adrenal adenomas. / Matsuda, Akira; Beniko, Mutsuo; Ikota, Akemi; Yamazaki, Masao; Koizumi, Shigeki; Mizumoto, Hiroaki; Watanabe, Takeo; Matsuya, Kumiko; Kunita, Haruhiko; Mashio, Yasuo; Sasano, Hironobu.

In: Internal Medicine, Vol. 35, No. 12, 12.1996, p. 970-975.

Research output: Contribution to journal › Article › peer-review

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abstract = "A 41-year-old woman developed primary aldosteronism due to bilateral multiple aldosterone-producing adenomas (APA), She was suspected to have idiopathic hyperaldosferonism (IHA) 7 years previously. Although preoperative data suggested APA and IHA was suspected in a postoperative microscopic specimen, a definite clinical diagnosis could not be made. Cytochrome P-450 and other enzymes involved in aldosterone synthesis were found in the tumor portions but not in the zona glomerulosa of attached adrenals, which histopathologically showed {"}paradoxical hyperplasia{"}. This was a rare case of bilateral multiple APA, which could be differentiated from IHA by immunohistochemical analysis of adrenal steroidogenic enzymes.",

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author = "Akira Matsuda and Mutsuo Beniko and Akemi Ikota and Masao Yamazaki and Shigeki Koizumi and Hiroaki Mizumoto and Takeo Watanabe and Kumiko Matsuya and Haruhiko Kunita and Yasuo Mashio and Hironobu Sasano",

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AU - Beniko, Mutsuo

AU - Ikota, Akemi

AU - Yamazaki, Masao

AU - Koizumi, Shigeki

AU - Mizumoto, Hiroaki

AU - Watanabe, Takeo

AU - Matsuya, Kumiko

AU - Kunita, Haruhiko

AU - Mashio, Yasuo

AU - Sasano, Hironobu

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