Primary aldosteronism with bilateral multiple aldosterone-producing adrenal adenomas

Akira Matsuda, Mutsuo Beniko, Akemi Ikota, Masao Yamazaki, Shigeki Koizumi, Hiroaki Mizumoto, Takeo Watanabe, Kumiko Matsuya, Haruhiko Kunita, Yasuo Mashio, Hironobu Sasano

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7 Citations (Scopus)


A 41-year-old woman developed primary aldosteronism due to bilateral multiple aldosterone-producing adenomas (APA), She was suspected to have idiopathic hyperaldosferonism (IHA) 7 years previously. Although preoperative data suggested APA and IHA was suspected in a postoperative microscopic specimen, a definite clinical diagnosis could not be made. Cytochrome P-450 and other enzymes involved in aldosterone synthesis were found in the tumor portions but not in the zona glomerulosa of attached adrenals, which histopathologically showed "paradoxical hyperplasia". This was a rare case of bilateral multiple APA, which could be differentiated from IHA by immunohistochemical analysis of adrenal steroidogenic enzymes.

Original languageEnglish
Pages (from-to)970-975
Number of pages6
JournalInternal Medicine
Issue number12
Publication statusPublished - 1996 Dec


  • Aldosterone-producing adenoma
  • Bilateral adrenocortical lesions
  • Steroidogenic enzymes

ASJC Scopus subject areas

  • Internal Medicine


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