Prevention of postoperative adhesions by a novel honeycomb-patterned poly(lactide) film in a rat experimental model

Yukako Fukuhira, Masaya Ito, Hiroaki Kaneko, Yoshihiko Sumi, Masaru Tanaka, Sadaaki Yamamoto, Masatsugu Shimomura

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    43 Citations (Scopus)

    Abstract

    Intraperitoneal adhesion is a serious problem concerning abdominal surgery. This study evaluated the performance of a honeycomb-patterned poly(lactide) (HCPLA) film as a physical barrier for preventing postoperative adhesion. HCPLA films were prepared using dioleoylphosphatidylethanolamine (DOPE) or a copolymer of dodecylacrylamide and ω-carboxyhexylacrylamide (CAP) as a surfactant (HCPLA-DOPE and HCPLA-CAP, respectively). In an in vivo adhesion prevention experiment, male Sprague-Dawley rats underwent standard cecum abrasion before midline laparotomy. We placed 2 cm x 2 cm HCPLA and flat films on the gliding interfaces; untreated rats formed the control group. After 1 week, adhesion was scored from 0 to 4. No significant difference was observed in the scores among groups, but macroscopic differences in adhesion prevention were observed. The adhesive strength of HCPLA-DOPE (18.1 ± 1.2 g) to skinless chicken breast was significantly higher than that of the flat film (15.2 ± 0.8 g, p < 0.05). Further, the adhesion score after 1 week for the HCPLA-DOPE group (1.6 ± 0.2) was significantly lower than that for the control group (3.0 ±0.3, ñ< 0.05) but comparable to that for the Seprafilm™ group (1.4 ± 0.3). These results demonstrated the potential of HCPLA-DOPE as a physical barrier for preventing postoperative adhesion.

    Original languageEnglish
    Pages (from-to)353-359
    Number of pages7
    JournalJournal of Biomedical Materials Research - Part B Applied Biomaterials
    Volume86
    Issue number2
    DOIs
    Publication statusPublished - 2008 Aug 1

    Keywords

    • Animal model
    • Membrane
    • PLA
    • Surface modification
    • Tissue adhesion

    ASJC Scopus subject areas

    • Biomaterials
    • Biomedical Engineering

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