Abstract
We examined the efficacy of metallothionein induction in the prevention of the carcinogenic action of cis-platinum and melphalan administered repeatedly to mice over a relatively long period. The increased pulmonary metallothionein induced by bismuth or zinc compounds during the period of chemotherapy with cis-platinum or melphalan protected the mice from carcinogenesis of these drugs in the lung. These results suggested the efficacy of metallothionein inducers in suppression of carcinogenicity considered as a secondary effect of anticancer agents in cancer chemotherapy.
| Original language | English |
|---|---|
| Pages (from-to) | 4767-4768 |
| Number of pages | 2 |
| Journal | Cancer Research |
| Volume | 53 |
| Issue number | 20 |
| Publication status | Published - 1993 Oct |
ASJC Scopus subject areas
- Oncology
- Cancer Research