Prevention of Carcinogenicity of Anticancer Drugs by Metallothionein Induction

Masahiko Satoh, Yukihiro Kondo, Masaharu Mita, Ippei Nakagawa, Akira Naganuma, Nobumasa Imura

Research output: Contribution to journalArticlepeer-review

55 Citations (Scopus)

Abstract

We examined the efficacy of metallothionein induction in the prevention of the carcinogenic action of cis-platinum and melphalan administered repeatedly to mice over a relatively long period. The increased pulmonary metallothionein induced by bismuth or zinc compounds during the period of chemotherapy with cis-platinum or melphalan protected the mice from carcinogenesis of these drugs in the lung. These results suggested the efficacy of metallothionein inducers in suppression of carcinogenicity considered as a secondary effect of anticancer agents in cancer chemotherapy.

Original languageEnglish
Pages (from-to)4767-4768
Number of pages2
JournalCancer Research
Volume53
Issue number20
Publication statusPublished - 1993 Oct

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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