Conclusion: Preventing leakage of endolymph during vestibular destruction may be important in the acute phase. Objectives: Vestibulotomy causes significant decrease in the endocochlear potential (EP). The effect of artificial perilymph and distilled water administration during vestibulotomy on hearing preservation was evaluated in Hartley guinea pigs. Methods: Animals were divided into three groups: the epitympanic bulla was filled with artificial perilymph or distilled water, or was not filled with any solution (control group). The EP and [K+] were monitored using double-barrelled ion-selective microelectrodes in the second turn of the cochlea. Results: EP was not significantly different between the artificial perilymph and the distilled water groups, although both groups showed better preservation of EP compared with the control group. The [K+] was not significantly different between the three groups.
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