Prevalence of HTLV-I Antibody in Pulmonary Cryptococcosis

Shigeru Kohno, Hironobu Koga, Mitsuo Kaku, Akira Yasuoka, Shigefumi Maesaki, Ken ichi Tanaka, Kotaro Mitsutake, Haruko Matsuda, Jun Araki, Kohei Hara

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15 Citations (Scopus)


A retrospective study was done to determine the prevalence of anti-HTLV-I antibodies in patients with pulmonary cryptococcosis. None of the 19 patients with pulmonary cryptococcosis had underlying immunodeficiency. Anti-HTLV-I antibody was present in 6 (32%) of 19 patients with pulmonary cryptococcosis, a significantly higher prevalence than found in patients with bronchial asthma (4 (7%) of 58) (p<0.01, chi-square test). No statistical difference was noted when anti-HTLV-I antibody seropositivity was compared to that of patients with pulmonary tuberculosis (16% (17/105)), lung cancer (17% (22/129)) and pneumonia (9% (6/64)). A reduced cellular immunity as shown by lymphopenia, the CD4/CD8 ratio and purified protein derivative skin test was found in only 1 (5%) of 19, 2 (12%) of 17, and 6 (33%) of 18 patients, respectively. These results do not explain the susceptibility to pulmonary cryptococcosis in HTLV-I carriers. This is the first report of high prevalence of pulmonary cryptococcosis in HTLV-I carriers and it raises the question whether HTLV-I carriers are more susceptible to opportunistic infections and other malignancies probably due to subtle immunological abnormalities.

Original languageEnglish
Pages (from-to)13-18
Number of pages6
JournalTohoku Journal of Experimental Medicine
Issue number1
Publication statusPublished - 1992


  • HTLV-I carriers
  • anti-HTLV-I antibody
  • cryptococcosis

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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